The mechanism of Changshan, a traditional Chinese medicine for malaria fever, has been found

2013-01-04 classification: efficacy effect 0 people comment on four scientists (Huihao Zhou, Litao sun, Xiang Lei Yang and Paul Schimmel) reported in the new issue of American medical journal Nature that the mechanism of Changshan, a traditional Chinese medicine used to treat malaria and fever for thousands of years, was found to be mainly due to high-precision structural analysis The secret scientists of Changshan have known that halofuginone, the active ingredient in Changshan, can inhibit the immune system of human body, but no one knows its mechanism With the help of the present detailed structural analysis of atoms, it is shown that halofuginone is like a wrench stuck in the gear of the molecular machine of amination Aminoacylation is the key step in protein synthesis How the drug, which has been used for thousands of years to treat malaria and fever, works remains a mystery Now four scientists at the Scripps Institute in California have solved the mystery Said Dr Paul Schimmel of the Scripps Institute Paul Schimmel and postdoctoral researcher Huihao Zhou led the study Aminoacylation is a necessary step for tRNA binding amino acids in the process of mRNA translation into proteins, so as to transfer the binding amino acids to the continuously extended peptide chain The function of changshanone is to block the active site of aminoacylated tRNA synthetase and interfere with the binding of tRNA and amino acids Chinese medicine fields secrets to scientists at the Scripps Research Institute