The lungs are also important hemagnemic organs
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Last Update: 2020-12-07
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Source: Internet
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Author: User
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generally consider the function of the lungs to be breathing, but a new study in the United States has found that the lungs also have previously unknown blood-making functions. In animal experiments, about half of the plateplates in mice were produced in the lungs, which, more importantly, stored large amounts of hematopoietic ancestral cells and stem cells to restore the hematopoietic function of the damaged bone marrow.
researchers at the University of California, San Francisco
the surprising results in the online edition of the Journal of Technology. Lead author Mark Luney, a professor at the University of California, San Francisco, said: "This finding gives us a more complex understanding of lung function, which may play a key role in the formation of human blood. Using
imaging technique known as "dual photon living imaging", the researchers observed the activity of individual cells in the microvascular veins of the lungs of living mice and accidentally found a large number of cytocytes in the blood vessels of the lungs. Giant nucleocytes are responsible for producing plateplates, which have previously been observed in the lungs but are generally thought to be found mainly in the bone marrow.
researchers found that the giant nucleocytes in the blood vessels of the mice's lungs produced more than 10 million plateplates per hour, suggesting that more than half of the plateplates in the mice's blood were produced in the lungs, rather than the bone marrow.
also found that large amounts of hematopoietic stem cells and ancestral cells are stored outside the blood vessels of the lungs. Hematopoietic progenito cells refer to the progenito cells of various types of blood cells that multiply and differentiate under certain microencienties and certain factors, and they have lost the ability of multi-directional differentiation and can only be directed to one or more blood cell linees for proliferation and differentiation.
have designed several lung transplant experiments to study how cytopterytes, hematopoietic stem cells, and ancestral cells migrate between bone marrow and lungs in mice. It was found that cytocytes were produced in the bone marrow and then migrated to the lungs to produce plateplates, which may be due to the fact that the lungs are the ideal biological reactor for producing plateplates. When plateplates are reduced in mice, the lungs stored ancestral cells that can be activated to produce new cytocytes, restoring plate plateboard counts. When the bone marrow lacks hematopoietic stem cells, hematopoietic stem cells and ancestral cells in the lungs can enter the bone marrow and repair damage, participating in the production of different blood cells.
researchers say the latest findings are important for treating plateboard reduction and provide a new direction for studying how bone marrow and lungs can restore the health of the hematosis system by exchanging blood cells
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