The "lost" "life" of the vaginal flora changes the outcome of pregnancy

Abstract: Dysbiosis of the vaginal microbiota, such as a decrease in Lactobacillus spp.

For expectant mothers who have undergone a long period of preparation for pregnancy but miscarried, the child's "leave without saying goodbye" has caused indelible damage to the body and mind for life

Most spontaneous abortions occur in the first 10-11 weeks of pregnancy, and 50% of spontaneous abortions during this period are due to chromosomal abnormalities (Figure 1)

Figure 1.

Pregnancy requires a unique and dynamic immune environment that supports a healthy pregnancy, in a pro-inflammatory state

The reproductive tract microbiota is a key regulator of local inflammatory and immune pathways throughout pregnancy

Figure 2.

In this study, 167 pregnant women were studied

Research result

1.

2.

3.

The study's corresponding author, Professor Phillip Bennett, Department of Metabolism, Digestion and Reproduction at Imperial, said: "If the role of the vaginal microbiome in miscarriage can be confirmed by further studies, it means that good vaginal hygiene plays an important role in early pregnancy

Vaginal probiotic preparation improves vaginal microecology of pregnant women

The female reproductive tract is an open orifice, and a large number of microorganisms are distributed in the female reproductive tract, especially the lower reproductive tract composed of the vagina and cervix, forming a unique micro-ecological environment

The formation of the vaginal microecology dominated by lactobacilli is mainly related to the level of estrogen.

During pregnancy, due to higher estrogen levels, Lactobacillus breaks down glycogen and produces more lactic acid, resulting in a low pH environment that favors Candida growth, while elevated progesterone levels suppress the maternal immune system, so prone to vaginal microecological disorders

Table 1.

Data source: [4]｜Table: Biodiscovery editorial team

In order to apply probiotics to regulate the microecology of the female reproductive tract, researchers screened different lactic acid bacteria strains with probiotic effects in the female reproductive system and made different microecological preparations
.
In the 1980s, Professor Kang Bai of Dalian Medical University started the research on probiotics for female reproductive tract diseases, and screened Lactobacillus delbrueckii DM8909 for the treatment of bacterial vaginosis
.
However, compared with the probiotic preparations that regulate the intestinal microecology, the research progress of the probiotic preparations to improve the microecology of the female reproductive tract is relatively slow
.

Probiotics suitable for women are mainly screened by Professor Kang Bai of Dalian Medical University from the vaginal secretions of healthy women, Lactobacillus delbrueckii DM8909 produced by Inner Mongolia Shuangqi Pharmaceutical Co.
, Ltd.
and Streptococcus Enterococcus produced by Xi'an Zhenghao Biopharmaceutical Co.
,
Ltd.
Both have better effects in controlling various types of lower genital tract infections and clearing HPV infection
.

References:

[1] He Lin, Genetic Counseling Today [M], Beijing: People's Health Publishing House, 2019

[2]Grewal K, Lee YS, Smith A, et al.
Chromosomally normal miscarriage is associated with vaginal dysbiosis and localinflammation.
BMC Med.
2022 Jan 28;20(1):38.
doi: 10.
1186/s12916-021-02227- 7.
PMID: 35090453; PMCID: PMC8796436.

[3] Ravel J, Gajer P, Abdo Z, et al.
Vaginalmicrobiome of reproductive-age women.
Proc Natl Acad Sci US A.
2011 Mar 15;108Suppl 1(Suppl 1):4680-7.
doi: 10.
1073/pnas.
1002611107.
Epub 2010 Jun 3.
PMID: 20534435; PMCID: PMC3063603.

[4] He Hongpeng, Li Weiqiang, Gao Ge,
etc.
An overview of the application of vaginal probiotic preparations in the treatment of female reproductive tract diseases
.
Journal of Tianjin University of Science and Technology, 2021, DOI: 10.
13364/j.
issn.
1672-6510.
20210083