The link between gla glare, the immune system and Tenascin-C

at Bochum Ruhr University (RUB) studied the role of immune responses in glare development in mice. They showed that the inflammatory process was associated with the pathogenesis of the disease, and that the extracellular substation molecule Tenascin-C played a key role as a regulator of the immune response. Glamino is a common cause of blindness worldwide. Usually, the patient's in-eye pressure increases, but about 40% remains within the normal range. The results of the immune response were published online October 9, 2020 in the journal Frontiers in Immunology.The cooperative study was carried out by Dr Susanne Wiemann of the RUB Department of Cell Morphology and Molecular Neurobiology, Dr Jacqueline Reinhard and Professor Andreas Faissner, together with Dr Sabrina Reinehr and Professor Stephanie Joachim of the Experimental Eye Institute at University Eye.Tenascin-C affects inflammatory immune responseresearchers studied mice lacking Tenascin-C and compared them to animals with this protein. In both groups of animals, they induced autoimmune glaucup, similar to human glaucup.In mice without Tenascin-C, the behavior of small glial cells of immune cells in the central nervous system was different from in mice with Tenascin-C. Cells are less reactive and release more anti-inflammatory factors. However, in animals with Tenascin-C, small glial cells secrete more inflammatory factors.

retinal cell death increases byThe team also observed effects on retinal nerve cells, which transmit visual information from the eye to the brain and often die from glare damage. Mice with Tenascin-C died of significantly more retinal nerve cells than mice without Tenascin-C. In contrast to mice with Tenascin-C, the optic nerves of mice without Tenascin-C remained intact.The results showed that Tenascin-C works in the glare eye by regulating the inflammatory process. Susanne Wiemann said: "One day, this discovery may help with early glare diagnosis. "(Bio Valley)source: The link between glaucoma, the immune system and protein tenascin-COriginal source: Ross of the extracellular matrix Tenascin-C leads to the content of the reactive cytokine expression in autoimmune, Frontiers in Immunology, 2020, DOI: 10.3389/fimmu.2020.566279