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5 key mutations shared between OMICRON and mouse-adapted SARS-COV-2 strains
In November 2021, the World Health Organization (WHO) named SARS-CoV-2 variant B.
With the rapid spread of the Omicron virus and its emergence as the dominant strain of the virus in many countries, scientists have been eager to learn more about the variant and its origins
Recently, the Journal of Biosafety and Biosecurity published online an analysis paper on the Omicron variant by the team of Academician Xu Jianguo from the Chinese Center for Disease Control and Prevention and Professor Sun Yamin from the Institute of Public Health and Health of Nankai University.
This paper analyzes the characteristics of the new crown variant Omicron from the aspects of evolutionary status and mutation pattern, and deeply analyzes the mutation sites related to multiple mouse adaptations of the Omicron variant
While much work remains to be done before this theory can be confirmed, Professor Xu said, "Our study calculated the average number of mutations in the five VOCs and investigated key mutations in the viral S protein, the origin of infection
This mutational spectrum signature suggests that the virus has adapted to infect cells in mice
He added: "These findings suggest that researchers should focus on SARS-CoV-2 variants isolated from wild animals, particularly rodents
Link to full text: Y.
https://doi.
