The latest progress of "diabetic eye disease"! Discovery of new targets for DR therapy

Diabetic retinopathy (DR) is a complication caused by long-term diabetes, and abnormal blood vessel formation in the eye is a common phenomenon in DR that can eventually lead to vision loss
.
Recently, research published in the journal Theranotics showed that by restoring the function of ADAM10, a major exfoliative protein, the formation of abnormal blood vessels can be controlled in preclinical models, and ADAM10 may be a potential new target for the treatment of
DR.

Currently, DR affects about 103 million people
worldwide.
According to a study by the Centers for Disease Control and Prevention (CDC), DR is most common in people with diabetes, with almost one-third of patients suffering from the disease and is the leading cause of
visual impairment and blindness in working-age people worldwide.

DR is usually asymptomatic in its early stages and is usually diagnosed when the disease progresses significantly, but immediate therapeutic intervention
is often required.
Currently available DR treatment strategies include anti-VEGF (vascular endothelial growth factor) injections, yet only about half of DR patients respond
to treatment.

This finding provides key information for understanding the causes of DR and opens new avenues for the development of effective treatment options for DR, including in patients who do not respond well to treatment against VEGF.

The researchers also found the involvement of other unknown potential molecular participants in DR and the importance of
understanding their mechanistic role in effectively controlling or preventing abnormal blood vessel formation in DR patients' eyes.

Currently, the research team is exploring the potential of ADAM10 in various aspects of angiogenesis and how it can be translated into a treatment that
is beneficial to patients.

Reference: Asfa Alli-Shaik et al, System-wide vitreous proteome dissection reveals impaired sheddase activity in diabetic retinopathy, Theranostics (2022).
DOI: 10.
7150/thno.
72947

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