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Multiple sclerosis is a less common disabling disease in clinical neurology, but it greatly affects patients' daily activities, behavior and quality of life.
However, it can be detected in the early stages of the disease, such as clinical manifestations and MRI examinations.
The research team from Italy used MRI to determine 5 cognitive phenotypes in a horizontal study of 1212 multiple sclerosis patients and 196 healthy controls through cognitive assessment methods, each of which has With specific clinical and attributed magnetic resonance imaging characteristics, it provides new ideas for clinical diagnosis! The first type is to retain cognitive ability and retain functions in all cognitive tests.
In terms of MRI findings, this group of patients only showed that the volume of the thalamus was lower than that of the healthy control group.
The second type, slightly impaired verbal memory/semantic fluency, showed a slight decline in SRT and WLG.
The third type, mild-multifunctional impairment, showed mild cognitive decline in SRT, SCWT, SDMT and PASAT.
The fourth type, severe-multifunctional damage, has decreased performance in all tests, and the damage is more serious in PASAT and SCWT.
Patients with this phenotype may have serious impairments in attention and executive functions, such as cognitive interference suppression.
The fifth type, severe-severely impaired multi-function, severely reduced performance in all cognitive tests.
This phenotype is more common in the late stages of multiple sclerosis and corresponds to the late cognitive dysfunction in the study population.
This new classification of cognitive deficits can integrate EDSS scores into the definition of clinical disease classification, provide a theoretical basis for clinicians to choose treatment methods, and help formulate cognitive rehabilitation treatment plans.
Written by: Yuting Wang Editor: Yuting Wang References: De Meo E, Portaccio E, Giorgio A, Ruano L, Goretti B, Niccolai C, Patti F, Chisari CG, Gallo P, Grossi P, Ghezzi A, Roscio M, Mattioli F , Stampatori C, Simone M, Viterbo RG, Bonacchi R, Rocca MA, De Stefano N, Filippi M, Amato MP.
Identifying the Distinct Cognitive Phenotypes in Multiple Sclerosis.
JAMA Neurol.
2021 Apr 1;78(4):414-425 .
doi: 10.
1001/jamaneurol.
2020.
4920.
PMID: 33393981; PMCID: PMC7783596.
However, it can be detected in the early stages of the disease, such as clinical manifestations and MRI examinations.
The research team from Italy used MRI to determine 5 cognitive phenotypes in a horizontal study of 1212 multiple sclerosis patients and 196 healthy controls through cognitive assessment methods, each of which has With specific clinical and attributed magnetic resonance imaging characteristics, it provides new ideas for clinical diagnosis! The first type is to retain cognitive ability and retain functions in all cognitive tests.
In terms of MRI findings, this group of patients only showed that the volume of the thalamus was lower than that of the healthy control group.
The second type, slightly impaired verbal memory/semantic fluency, showed a slight decline in SRT and WLG.
The third type, mild-multifunctional impairment, showed mild cognitive decline in SRT, SCWT, SDMT and PASAT.
The fourth type, severe-multifunctional damage, has decreased performance in all tests, and the damage is more serious in PASAT and SCWT.
Patients with this phenotype may have serious impairments in attention and executive functions, such as cognitive interference suppression.
The fifth type, severe-severely impaired multi-function, severely reduced performance in all cognitive tests.
This phenotype is more common in the late stages of multiple sclerosis and corresponds to the late cognitive dysfunction in the study population.
This new classification of cognitive deficits can integrate EDSS scores into the definition of clinical disease classification, provide a theoretical basis for clinicians to choose treatment methods, and help formulate cognitive rehabilitation treatment plans.
Written by: Yuting Wang Editor: Yuting Wang References: De Meo E, Portaccio E, Giorgio A, Ruano L, Goretti B, Niccolai C, Patti F, Chisari CG, Gallo P, Grossi P, Ghezzi A, Roscio M, Mattioli F , Stampatori C, Simone M, Viterbo RG, Bonacchi R, Rocca MA, De Stefano N, Filippi M, Amato MP.
Identifying the Distinct Cognitive Phenotypes in Multiple Sclerosis.
JAMA Neurol.
2021 Apr 1;78(4):414-425 .
doi: 10.
1001/jamaneurol.
2020.
4920.
PMID: 33393981; PMCID: PMC7783596.
