The latest discovery of a protein gene in Japan offers hope for the treatment of cerebellar atrophy

Progress in the treatment of cerebellar atrophy in Japan According to Xinhua news agency, Tokyo (reporter LAN Jianzhong), Japanese researchers have found that the introduction of a gene encoding a repair protein into the cerebellum of mice suffering from cerebellar atrophy (SCA) can prolong the life of mice and improve their motor ability This finding provides hope for the treatment of cerebellar atrophy At present, the cause of cerebellar atrophy is not clear, but most patients have a family genetic tendency Because the physiological function of cerebellum is mainly to maintain body balance and coordinate random movement, patients often have symptoms such as gait instability, running difficulties, and heart failure in the late stage Okazawa, et al Of Tokyo University of medical dentistry, studied cerebellar atrophy type 1 It is known that the sixth chromosome of the patient is abnormal, resulting in the decrease of HMGB1 protein in nerve cells which can repair damaged DNA The team introduced genes that encode HMGB1 protein into the cerebellum surface of the diseased mice The results showed that the life span of the mice with a previous life span of only 250 days was prolonged after the introduction of the gene, and the motor function was also improved If HMGB1 protein is injected directly, it will activate inflammatory cells and have adverse effects, the researchers said In gene therapy, only the protein in nerve cells increased, so it is expected to develop a new method for the treatment of cerebellar atrophy in the future.