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The latest clinical application of Eltanexor in the treatment of MDS refractory to demethylation drugs...

 Last Update: 2021-06-20
 Source: Internet
 Author: User

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On June 9th, Karyopharm Therapeutics, a partner of Deqi Pharmaceuticals, announced at the 2021 American Society of Clinical Oncology (ASCO) annual meeting that eltanexor was used to treat myelodysplastic syndrome (MDS) refractory to demethylation drugs (HMA).

The trial is a phase I/II clinical study aimed at evaluating single-agent eltanexor in the treatment of higher-risk MDS patients, that is, according to the International Prognostic Scoring System (IPSS) assessed as intermediate-risk-2 or high-risk MDS patients, and the proportion of bone marrow blasts It is 5-19%

Among the 20 patients enrolled in the group, 15 patients can be evaluated for efficacy

MDS patients refractory to demethylation drugs have limited treatment options and poor prognosis.

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