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Evaluating the effectiveness of cancer treatment is a key issue, and tools that can monitor changes in tumor size in real time are key to
Using electronic materials, the researchers designed a wearable strain sensor that can measure and record changes in
Figure 1 Research results (Source: [1])
The FAST sensor is made by depositing a 50 nm gold layer on top of the styrene-ethylene-butene-styrene drip casting layer, which is prone to expansion or contraction as the tumor progresses
Custom-designed printed circuit boards and mobile applications for this sensor enable real-time and historical sensor readings at the push of a
Figure 2 Sensor device for measuring tumor volume change (Source: [1])
To verify its ability to discern shape-volume changes in vitro, the researchers measured the output of the sensor when placed on top of a 3D printed model tumor, and they found that the sensor recorded significant changes
Subsequently, the researchers once again verified the accuracy and effectiveness of the sensor in measuring changes in tumor volume in vivo
Next, the researchers also used erlotinib as an example to evaluate how the FAST sensor measured the volume of tumors in mice during treatment
Fig.
Finally, the researchers used experimental immunotherapy to perform sensor characterization of Balb/c mice's A20B cell lymphoma solid tumor model to demonstrate the accuracy and effectiveness of sensor monitoring in multiple tumor models and treatment modalities
In this regard, the researchers said that the miniature device they designed this time, the flexible autonomous sensor (FAST) that measures tumors, represents a new, fast, cheap, portable and accurate way to
Resources:
[1] Abramson A, Chan CT, Khan Y, et al.