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On August 30, 2022, the team of Zhu Di of the School of Basic Medicine of Fudan University and the team of Xu Jianmin of Zhongshan Hospital Affiliated to Fudan University published a research paper entitled Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers in Cell Reports
Liver metastasis is one of the most important reasons affecting the prognosis of colon cancer, and its incidence and mortality are high
Recent studies have shown that the tumor immune microenvironment plays an important role in the progression of cancer
The authors first detected and compared the immune microenvironment composition of the primary tumor of colon cancer patients with liver metastases and non-metastatic patients by single-cell sequencing, and found that B cells and their subgroups of activated B cells in the primary tumor samples of colon cancer patients with liver metastases were significantly decrease
By analyzing the differentiation trajectory of B cells, the authors found that B cell differentiation is closely related to liver metastasis
Through further analysis, the authors identified a group of cells associated with the differentiation of activated B cells into plasma cells
The authors constructed a mouse liver metastasis model and demonstrated that activated B cells can significantly inhibit liver metastasis
Figure 1.
In conclusion, this study revealed that activated B cells were significantly reduced in the primary tumor of colon cancer liver metastases by single-cell sequencing technology, and for the first time discovered a new type of B cells associated with left and right colon cancer heterogeneity and colon cancer liver metastasis.
Zhu Di from the School of Basic Medicine of Fudan University, and Professor Xu Jianmin from Zhongshan Hospital Affiliated to Fudan University are the co-corresponding authors of this article
Reference: Xu et al.
The corresponding author and lead contact of this article, Zhu Di, is a national young special expert, dedicated to tumor immunopharmacology research.
