China News Service, Guangzhou, November 25 (Reporter Guo Jun) The Institute of Biomedical Translational Research of Jinan University Medical Department held a press conference in Guangzhou on the 25th to announce that the team of Professor Yin Zhinan of the hospital has worked hard for 7 years in the field of obesity and metabolic diseases.
Related research papers were published online on November 24 in the top international academic journal Nature
According to reports, adipocytes are divided into white fat, brown fat and beige fat according to their morphology, metabolism, location and development
Professor Yin Zhinan’s team built a high-fat diet-induced obesity model in mice, and combined with samples of obese people, they found that the level of IL-27 in the serum of obese people decreased, and for the first time found that IL-27 can directly act on non-immune cells--fat Cells, causing white adipocytes to brown, and activate the key protein of thermogenesis-uncoupling protein UCP1 mediated "fat burning"; by converting the lipids in adipose tissue into calories for consumption, so as to reduce weight and improve The purpose of metabolic diseases such as diabetes
According to reports, this is also the first time researchers have discovered that IL-27 in the IL-12 cytokine family can directly act on adipocytes and cause adipocyte differentiation and thermogenesis, providing a new target for the treatment of obesity and metabolic diseases
In recent years, obesity-induced metabolic syndromes such as type 2 diabetes, non-alcoholic fatty liver, and atherosclerosis have become major public health challenges
This research is strongly supported by the key research and development program of the Ministry of Science and Technology of China, the key project of the National Natural Science Foundation of China, the discipline innovation and intelligence introduction base of the Ministry of Education, and the high-level hospital discipline construction funding of Zhuhai People's Hospital
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