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Uridine 5' tetraphosphate (5'TUP), also known as uridine 5'-O-(2-oxa-bicyclo[2.
2.
1]hept-2-yl)tetrachlorophenyl-tetrahydrofuran-2,3,5-triazium-3-oxidazolidin-4-one, is a synthetic molecule with a long and complex name.
It is commonly used in the chemical industry as a phosphorylating agent, a ligand for metal complexes, and as a building block for the synthesis of nucleoside analogs.
Uridine 5' tetraphosphate is a white to off-white, odorless, and hygroscopic solid that is soluble in water and many organic solvents.
It is a potent inhibitor of ribonucleotide reductase, an enzyme that plays a key role in regulating the levels of deoxyribonucleotides in cells.
By inhibiting ribonucleotide reductase, 5'TUP leads to an accumulation of deoxyribonucleotides, which in turn triggers cell death.
This property makes 5'TUP and its derivatives useful as antiproliferative agents, as they can be used to inhibit the growth of cancer cells.
Another application of 5'TUP is in the synthesis of nucleoside analogs.
Nucleoside analogs are modified versions of the building blocks of DNA and RNA that can be used to study the structure and function of these molecules.
5'TUP can be used as a phosphorylating agent to add a phosphate group to a nucleoside, which is a critical step in the synthesis of many nucleoside analogs.
This makes 5'TUP an important intermediate in the synthesis of many nucleoside analogs, which are used in a wide range of applications, including the development of new drugs, the study of molecular biology, and the creation of genomic and proteomic tools.
In addition to its uses in the chemical industry, 5'TUP has also been investigated as a potential therapeutic agent.
Studies have shown that 5'TUP can inhibit the growth of cancer cells in vitro and in vivo, suggesting that it may have potential as an anticancer drug.
However, further research is needed to fully understand the potential therapeutic effects of 5'TUP and to determine its safety and efficacy in humans.
In conclusion, Uridine 5' tetraphosphate (5'TUP) is a versatile and important molecule in the chemical industry, with a wide range of applications in the synthesis of nucleoside analogs, as a phosphorylating agent, and as a potential therapeutic agent.
Its ability to inhibit ribonucleotide reductase and accumulate deoxyribonucleotides makes it a promising antiproliferative agent, and its use as an intermediate in the synthesis of nucleoside analogs has opened up new avenues of research in the fields of molecular biology and drug development.