The Instruction of Methyl (1R,2S,3S,5S)-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate

The Instruction of Methyl (1R,2S,3S,5S)-3-(3,4-dichlorophenyl)-8-azabicyclo[3.
2.
1]octane-2-carboxylate: A Comprehensive Guide for the Chemical Industry

Methyl (1R,2S,3S,5S)-3-(3,4-dichlorophenyl)-8-azabicyclo[3.
2.
1]octane-2-carboxylate, also known as (1R,2S,3S,5S)-2-(3,4-dichlorophenyl)-8-azabicyclo[3.
2.
1]octan-3-carboxylic acid, is a synthetic chemical compound that is commonly used in the chemical industry.
This compound is a whitish solid that is soluble in organic solvents and is used as an intermediate in the synthesis of various chemicals and pharmaceuticals.

In this article, we will provide a comprehensive guide to the instruction of methyl (1R,2S,3S,5S)-3-(3,4-dichlorophenyl)-8-azabicyclo[3.
2.
1]octane-2-carboxylate, including its chemical properties, synthesis, applications, and safety measures.

Chemical Properties

Methyl (1R,2S,3S,5S)-3-(3,4-dichlorophenyl)-8-azabicyclo[3.
2.
1]octane-2-carboxylate is a carboxylic acid that belongs to the class of azabicyclo[3.
2.
1]octane derivatives.
This compound is a white solid that is soluble in organic solvents such as ethanol, acetonitrile, and dichloromethane.
The compound has a molecular formula of C15H12Cl2N2O2 and a molecular weight of 272.
19 g/mol.

The compound exhibits weak acidic properties, with a pKa value of around 5.
5.
It is also a substrate for various enzymes, including CYP3A4 and CYP2C9, which are responsible for its metabolism in the body.

Synthesis

Methyl (1R,2S,3S,5S)-3-(3,4-dichlorophenyl)-8-azabicyclo[3.
2.
1]octane-2-carboxylate can be synthesized through various methods, depending on the desired yield and purity of the product.
Some of the commonly used methods for synthesizing this compound include:

• Reductive alkylation of 3,4-dichlorophenylamine with 2-(4-nitrophenyl)acetate in the presence of hydride reducing agents such as lithium aluminum hydride (LiAlH4) or diisobutylaluminum hydride (DIBAH).
  
• Reductive nitration of 2-nitro-1,3-benzoxazepine with 3,4-dichlorophenylamine in the presence of a reducing agent such as sodium borohydride (NaBH4).
  
• Direct nitration of 3,4-dichlorophenylamine with nitric acid (HNO3) in the presence of a catalyst such as aluminum chloride (AlCl3).
  

Applications

Methyl (1R,2S,3S,5S)-3-(3,4-dichlorophenyl)-8-azabicyclo[3.
2.
1]octane-2-carboxylate is used as an intermediate in the synthesis of various chemicals and pharmaceuticals.
Some of its applications include:

• It can be converted into other azabicyclo[3.
  2.
  1]octane derivatives through various chemical reactions, such as alkylation, nitration, and sulfonation.
  
• It can be used as a building block for the synthesis of hit-to-lead compounds in pharmaceutical research.
  
• It can be used as a catalyst or a catalyst precursor in various chemical reactions, such as polymerization and hydros