The Instruction of Imidazo[1,2-b]pyridazine-2-carboxylic acid (9CI)

Imidazo[1,2-b]pyridazine-2-carboxylic acid (9CI) is an important intermediate in the chemical industry and is widely used in the production of various chemicals, drugs, and materials.

Its chemical formula is C7H6N4O2, and its molecular weight is 144.
15 g/mol.
The molecule has a simple structure consisting of a six-membered imidazo ring fused to a five-membered pyridazine ring, with a carboxylic acid group (-COOH) attached to the 2-position of the pyridazine ring.

The synthesis of 9CI typically involves the reaction of a substituted imidazole with a substituted pyridine in the presence of a strong acid catalyst, such as hydrochloric acid or sulfuric acid.
The reaction leads to the formation of an imidazo[1,2-b]pyridazine-2-carboxylic acid derivative, which can be further transformed into the desired 9CI through various chemical reactions, such as esterification, amidation, or halogenation.

One of the key applications of 9CI is in the production of pharmaceuticals and agrochemicals.
For example, it can be used as an intermediate for the synthesis of the antimalarial drug quinine, as well as the herbicide paraquat.
It is also used in the production of dyes, photographic chemicals, and other chemical products.

The demand for 9CI is expected to grow in the coming years due to its increasing use in the production of various chemicals and materials.
As a result, there is a growing need for efficient and cost-effective methods for its synthesis and purification.

One of the challenges in the synthesis of 9CI is the purification of the final product, which often contains impurities that can affect its quality and efficacy.
Various purification methods, such as crystallization, recrystallization, and chromatography, are commonly used to remove the impurities and obtain a pure sample of 9CI.

In conclusion, imidazo[1,2-b]pyridazine-2-carboxylic acid (9CI) is an important intermediate in the chemical industry and has a wide range of applications in the production of various chemicals, drugs, and materials.
Its synthesis typically involves the reaction of a substituted imidazole with a substituted pyridine in the presence of a strong acid catalyst, and the resulting derivative can be further transformed into the desired 9CI through various chemical reactions.
The demand for 9CI is expected to grow in the coming years, and there is a need for efficient and cost-effective methods for its synthesis and purification.