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Introduction:
Cinchonanium, 9-hydroxy-1-(phenylmethyl)-, chloride, (8α,9R)-, also known as Cinchonine, is a pharmaceutical compound that is widely used in the treatment of malaria.
It is an alkaloid that is derived from the bark of the cinchona tree, also known as the quinine tree, which is native to the Andes region of South America.
This compound is used in the production of various medications and is also used in the treatment of other conditions such as as a antiparkinson drug.
Chemical Structure:
Cinchonanium, 9-hydroxy-1-(phenylmethyl)-, chloride, (8α,9R)-, is a white to yellowish-white, crystalline powder that is soluble in water and slightly soluble in ethanol.
Its molecular formula is C18H26ClNO2 and it has a molecular weight of 366.
8 g/mol.
Its chemical structure can be represented as follows:
([A-B]-[C-D])([H+] = [A-B]-[C-D])
Production:
Cinchonanium, 9-hydroxy-1-(phenylmethyl)-, chloride, (8α,9R)-, is produced through a series of chemical reactions that involve the isolation and purification of the alkaloid from the bark of the cinchona tree.
The bark is extracted using a mixture of water and organic solvents, and the resulting solution is then filtered and concentrated.
The residue is then treated with various reagents to isolate the alkaloid, which is then purified through a series of chromatography and crystallization steps.
Applications:
Cinchonanium, 9-hydroxy-1-(phenylmethyl)-, chloride, (8α,9R)-, has a wide range of applications in the pharmaceutical industry.
It is primarily used as an anti-malarial drug and is also used in the treatment of other conditions such as Parkinson's disease.
It is also used in the production of various research chemicals, which are used in scientific research and development.
Malaria treatment:
Cinchonanium, 9-hydroxy-1-(phenylmethyl)-, chloride, (8α,9R)-, is primarily used as an anti-malarial drug due to its ability to prevent the growth of the Plasmodium falciparum parasite, which is the most deadly species of the parasite that causes malaria.
It works by inhibiting the activity of the enzyme glycogen synthase kinase-3beta, which is involved in the regulation of glycogen metabolism in the parasite.
This inhibition leads to an accumulation of glycogen in the parasite, which ultimately leads to its death.
Parkinson's disease treatment:
Cinchonanium, 9-hydroxy-1-(phenylmethyl)-, chloride, (8α,9R)-, is also used in the treatment of Parkinson's disease.
It is believed to work by inhibiting the activity of the enzyme monoamine oxidase, which is involved in the breakdown of certain neurotransmitters in the brain.
This inhibition leads to an increase in the levels of these neurotransmitters, which can help to alleviate the symptoms of Parkinson's disease.
Research Chemicals:
Cinchonanium, 9-hydroxy-1-(phenylmethyl)-, chloride, (8α,9R)-, is also used in the production of various research chemicals.
These chemicals are used in scientific research and development, and are