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Axitinib is a drug that is used to treat kidney and liver cancer.
It is a small molecule inhibitor that works by blocking the activity of a protein called tyrosine kinase, which is involved in cell growth and division.
Axitinib is a targeted therapy, which means it only attacks cancer cells and leaves healthy cells unharmed.
This makes it an effective treatment option for patients with cancer who have exhausted other treatment options.
In this article, we will discuss the instruction of axitinib in the chemical industry, including its chemical properties, production process, and uses.
Chemical Properties of Axitinib
Axitinib is a small molecule inhibitor that is composed of a benzoxazepine skeleton with a phenylalanine side chain.
It has a molecular weight of 409.
5 g/mol and a solubility of 5 mg/mL in water.
Axitinib is a white to off-white powder that is practically insoluble in ethanol and acetonitrile.
It is stable under normal storage conditions and does not require special handling or storage.
Production Process of Axitinib
The production process for axitinib involves several steps, including synthesis, purification, and formulation.
The synthesis of axitinib involves a multi-step process that involves the coupling of several building blocks.
The purification process involves the use of high-performance liquid chromatography (HPLC) to separate the impurities from the active ingredient.
Finally, the axitinib is formulated into the required dosage forms, such as tablets or capsules.
Uses of Axitinib
Axitinib is used to treat advanced kidney and liver cancer.
It is approved for use in over 90 countries and has been used to treat over 150,000 patients worldwide.
Axitinib is effective in treating different types of kidney cancer, including clear cell, papillary, and chromophobe.
It is also effective in treating liver cancer, including hepatocellular carcinoma.
Axitinib works by blocking the activity of the tyrosine kinase protein, which is involved in cell growth and division.
By blocking this protein, axitinib inhibits the growth and proliferation of cancer cells.
It also enhances the ability of the immune system to attack cancer cells.
Axitinib is a targeted therapy, which means it only attacks cancer cells and leaves healthy cells unharmed.
This makes it an effective treatment option for patients with cancer who have exhausted other treatment options.
Conclusion
Axitinib is a drug that is used to treat kidney and liver cancer.
It is a small molecule inhibitor that works by blocking the activity of a protein called tyrosine kinase, which is involved in cell growth and division.
Axitinib is a targeted therapy, which means it only attacks cancer cells and leaves healthy cells unharmed.
This makes it an effective treatment option for patients with cancer who have exhausted other treatment options.
The production process for axitinib involves several steps, including synthesis, purification, and formulation.
It is a white to off-white powder that is practically insoluble in ethanol and acetonitrile.
It is stable under normal storage conditions and does not require special handling or storage.
Axitinib is a valuable treatment option for patients with cancer, and ongoing research is focused on improving its efficacy and safety.