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Abstract:
In this article, we will explore the instruction of 6-methyl-3-pyridazinedicarboxylic acid, an important chemical compound widely used in the chemical industry.
The article will cover the properties, synthesis, and applications of 6-methyl-3-pyridazinedicarboxylic acid, as well as its safety precautions and handling procedures.
Introduction:
6-methyl-3-pyridazinedicarboxylic acid, commonly referred to as 3-methyl-2-oxo-2,3-dihydro-1H-pyrazolidin-1-one, is a white to off-white, odorless solid that is soluble in water.
It is used as a building block in organic synthesis and as an intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals.
Properties:
3-methyl-2-oxo-2,3-dihydro-1H-pyrazolidin-1-one has a molecular formula of C5H6N2O2 and a molecular weight of 127.
13 g/mol.
It has a melting point of 250-252°C and a boiling point of 370-372°C.
Its density is 1.
38 g/cm3, and its solubility in water is 10 g/100 mL at 25°C.
Synthesis:
3-methyl-2-oxo-2,3-dihydro-1H-pyrazolidin-1-one can be synthesized through several methods, including the following:
- Hydrolysis of N-(2-chloro-4-nitrophenyl)acetamide: This synthesis involves the hydrolysis of N-(2-chloro-4-nitrophenyl)acetamide in aqueous sodium hydroxide solution to yield 3-methyl-2-oxo-2,3-dihydro-1H-pyrazolidin-1-one.
- Reaction of 2-aminopyridine with malonic acid: This synthesis involves the reaction of 2-aminopyridine with malonic acid in the presence of a catalyst, such as hydrochloric acid, to yield 3-methyl-2-oxo-2,3-dihydro-1H-pyrazolidin-1-one.
- Cyclization of 2,6-dimethylpyridine-3-acetaldehyde: This synthesis involves the cyclization of 2,6-dimethylpyridine-3-acetaldehyde in the presence of an acid catalyst, such as hydrochloric acid, to yield 3-methyl-2-oxo-2,3-dihydro-1H-pyrazolidin-1-one.
Applications:
3-methyl-2-oxo-2,3-dihydro-1H-pyrazolidin-1-one is used as a building block in organic synthesis and as an intermediate in the production of various chemicals, including pharmaceuticals, agrochemicals, and other fine chemicals.
Pharmaceuticals:
3-methyl-2-oxo-2,3-dihydro-1H-pyrazolidin-1-one is used in the production of drugs, such as ACE inhibitors and antiepileptic drugs.
It is also used as an intermediate in the synthesis of other drugs, such as antibiotics and antiviral drugs.
Agrochemicals:
3-methyl-2-oxo-2,3-d
