Instruction of 5-Chloro-6-ethylpyrimidin-4-ol: A Comprehensive Guide for the Chemical Industry

Introduction

5-Chloro-6-ethylpyrimidin-4-ol, often abbreviated as 5E is a halogenated pyrimidine derivative with a wide range of applications in the chemical industry.
It has a unique structure and properties that make it ideal for use in various chemical reactions.
This article provides comprehensive instructions for the use of 5-Chloro-6-ethylpyrimidin-4-ol, including its properties, synthesis methods, safety precautions, and applications.

Properties of 5-Chloro-6-ethylpyrimidin-4-ol

Physical Properties

5-Chloro-6-ethylpyrimidin-4-ol is a white to off-white crystalline solid with a melting point of 179-181°C.
Its molecular formula is C8H11ClN3O, and it has a molecular weight of 285.
72 g/mol.
5-Chloro-6-ethylpyrimidin-4-ol is soluble in water, ethanol, and other organic solvents.
It is a polar molecule with a high polarity of 6.
869.

Chemical Properties

5-Chloro-6-ethylpyrimidin-4-ol undergoes a variety of chemical reactions, including nucleophilic substitution, electrophilic substitution, and condensation reactions.
It can be converted into a wide range of derivatives, including 6-ethylpyrimidine-5-carboxylic acid, 6-ethylpyrimidine-5-vinylamine, and 6-ethyl-5,7-dihydroimidazo[1,2-d]pyrimidine.

Synthesis Methods for 5-Chloro-6-ethylpyrimidin-4-ol

There are several methods available for the synthesis of 5-Chloro-6-ethylpyrimidin-4-ol, including:

Method 1: Bromination of 5-Ethylpyrimidine-2,4-dione

This method involves the bromination of 5-Ethylpyrimidine-2,4-dione using N-Bromosuccinimide (NBS) and benzene as solvent.
The reaction is exothermic and requires careful monitoring of the temperature.
The reaction mixture is then filtered and the filtrate is concentrated to obtain pure 5-Chloro-6-ethylpyrimidin-4-ol.

Method 2: From 5-Ethyl-2,5-dimethylpyrimidine-6-sulfonic Acid

This method involves the sulfonation of 5-Ethyl-2,5-dimethylpyrimidine-6-sulfonic acid using chlorosulfonic acid.
The resulting 5-Ethyl-6-chloro-2,5-dimethylpyrimidine is then cyclized to obtain 5-Chloro-6-ethylpyrimidin-4-ol.

Safety Precautions for 5-Chloro-6-ethylpyrimidin-4-ol

5-Chloro-6-ethylpyrimidin-4-ol should be handled with caution as it is a hazardous chemical.
It should be stored in a cool, dry, and well-ventilated area away from direct