The Instruction of (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide

Instruction of (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide: A Comprehensive Guide for Chemical Industry

The chemical industry has been playing an essential role in shaping the world's economy for decades.
The industry involves the production and processing of various chemical compounds that are used in different sectors such as healthcare, pharmaceuticals, agriculture, and manufacturing.
As the industry continues to evolve, researchers and scientists are constantly working on developing new and innovative chemical compounds that can meet the demands of the market.
One such compound is (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide.

Introduction

(4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide is a synthetic compound belonging to the class of carboxamides.
The compound has a unique chemical structure that makes it an attractive candidate for various applications.
In this article, we will provide a comprehensive guide to the instruction of (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide, including its synthesis, chemical properties, and potential applications.

Synthesis of (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide

The synthesis of (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide involves several steps, including the preparation of starting materials, anhydrous reagents, and a suitable solvent.
Here is the step-by-step synthesis procedure:

Step 1: Preparation of starting materials

• 4-Cyano-2-methoxyphenyl amide: To a solution of 4-cyano-2-methoxy anilide (2 g, 10 mmol) in acetonitrile (50 mL), a solution of sodium hydroxide (1.
  5 g, 37 mmol) in water (25 mL) was added.
  The reaction mixture was stirred at room temperature for 18 hours, and the precipitated solid was filtered and washed with water to give 4-cyano-2-methoxyphenyl amide as a white solid (2.
  5 g, 9.
  5 mmol, 95% yield).
  
• Ethyl 3-methylthiopropionate: To a solution of 3-methylthiopropionic acid (2 g, 15 mmol) in dichloromethane (50 mL), a solution of triethylamine (2.
  2 mL, 15.
  6 mmol) in dichloromethane (10 mL) was added.
  The reaction mixture was stirred at room temperature for 18 hours, and the solvent was evaporated under reduced pressure.
  The residue was subjected to column chromatography over silica gel (eluent: hexanes-ethyl acetate, 9:1), and the desired fractions were collected and combined to give ethyl 3-methylthiopropionate as a pale yellow oil (1.
  5 g, 7.