The Instruction of 4-(Trifluoromethyl)-2-pyrimidinethiol

4-(Trifluoromethyl)-2-pyrimidinethiol, also known as FTN-Py, is a common intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other chemical products.
This compound is used as a building block for the synthesis of other thiol-containing compounds, and it can be converted into a wide range of products with different chemical and physical properties.

The synthesis of 4-(Trifluoromethyl)-2-pyrimidinethiol typically involves several steps, starting with the synthesis of 2-pyrimidinethiol.
This compound is typically synthesized by reacting 2-aminomethylpyrimidine with hydrogen sulfide in the presence of a strong acid catalyst, such as sulfuric acid or phosphoric acid.
The resulting compound is then converted into 4-(Trifluoromethyl)-2-pyrimidinethiol by reacting it with trifluoromethyl iodide in the presence of a Lewis acid catalyst, such as zinc iodide or aluminum trichloride.

The selection of the appropriate synthesis route and the choice of the synthesis method can have a significant impact on the yield and the purity of the final product.
The optimal synthesis route and the synthesis method will depend on various factors, including the availability of starting materials, the desired purity of the final product, and the cost of the synthesis.

One of the most common methods for synthesizing 4-(Trifluoromethyl)-2-pyrimidinethiol is the synthesis route using zinc iodide as the Lewis acid catalyst.
This synthesis route typically involves the following steps:

1. Preparation of the starting materials: 2-aminomethylpyrimidine and trifluoromethyl iodide.
   
2. Synthesis of 2-pyrimidinethiol: 2-aminomethylpyrimidine is reacted with hydrogen sulfide in the presence of a strong acid catalyst, such as sulfuric acid or phosphoric acid, to form 2-pyrimidinethiol.
   
3. Synthesis of 4-(Trifluoromethyl)-2-pyrimidinethiol: 2-pyrimidinethiol is reacted with trifluoromethyl iodide in the presence of zinc iodide as the Lewis acid catalyst to form 4-(Trifluoromethyl)-2-pyrimidinethiol.
   
4. Purification of the product: The resulting 4-(Trifluoromethyl)-2-pyrimidinethiol is typically purified by recrystallization or by chromatography.
   

The synthesis of 4-(Trifluoromethyl)-2-pyrimidinethiol using zinc iodide as the Lewis acid catalyst has several advantages, including the high yield of the desired product, the ease of the synthesis route, and the low cost of the synthesis.
However, this synthesis route also has some disadvantages, such as the potential for the formation of unwanted side products and the need for the strict control of the reaction conditions.

Another synthesis route for 4-(Trifluoromethyl)-2-pyrimidinethiol involves the use of aluminum trichloride as the Lewis acid catalyst.
This synthesis route typically involves the following steps:

1. Preparation of the starting materials: 2-aminomethylpyrimidine and trifluoromethyl iodide.
   
2. Synthesis of 2-pyrimidinethiol: 2-aminomethylpyrimidine is reacted with hydrogen sulfide in the presence of a strong acid catalyst, such as sulfuric acid or phosph