The Instruction of 3-Chloro-4-methyl-6-phenylpyridazine

The production of 3-chloro-4-methyl-6-phenylpyridazine (CMPP) is an important process in the chemical industry, as this compound is widely used as an intermediate in the production of various pharmaceuticals, agrochemicals, and other chemical products.
In this article, we will discuss the process of producing CMPP in a chemical plant, including the key steps involved and the equipment required.

Step 1: Nitric acid treatment

The first step in the production of CMPP is the nitric acid treatment of 4-methyl-6-phenylpyridazine (MPP).
This is done to convert the tertiary amine group in MPP into a nitro group, which makes it more reactive and easier to convert into CMPP.

The MPP is reacted with nitric acid in the presence of a solvent, such as water or acetic acid, to form a nitrate salt.
The reaction is typically carried out at a temperature of 50-70°C and a concentration of 60-70% nitric acid.

Step 2: Nitration

The next step in the production of CMPP is the nitration of the nitrate salt obtained from the nitric acid treatment.
This is done by treating the nitrate salt with a mixture of nitrating agents, such as nitric acid and sulfuric acid, in the presence of a solvent, such as water or acetic acid.

The reaction is typically carried out at a temperature of 70-90°C and a concentration of 70-80% nitric acid and 20-30% sulfuric acid.
The reaction is exothermic, and it is essential to control the temperature carefully to prevent unwanted side reactions.

Step 3: Chlorination

After the nitration step, the next step in the production of CMPP is the chlorination of the nitrate salt.
This is done to convert the nitrate group into a chloride group.

The chlorination is typically carried out by treating the nitrate salt with chlorine gas in the presence of a solvent, such as water or acetic acid.
The reaction is exothermic, and it is essential to control the temperature carefully to prevent unwanted side reactions.

Step 4: Reduction

The final step in the production of CMPP is the reduction of the chlorinated nitrate salt to form the final product.
This is done to convert the chloride group into a methyl group.

The reduction is typically carried out by treating the chlorinated nitrate salt with a reducing agent, such as hydrogen gas or an organic reducing agent, in the presence of a solvent, such as water or acetic acid.
The reaction is typically carried out at a temperature of 200-300°C and a pressure of 1-5 bar.

Equipment Required

The production of CMPP requires a range of equipment, including reaction vessels, agitators, temperature controllers, pressure controllers, and other associated equipment, such as pipes, valves, and pumps.
The type and size of the equipment required will depend on the scale of the production, the specific process conditions, and the safety requirements.

In addition to the above equipment, the production of CMPP also requires a control system to monitor and control the reaction conditions, such as temperature, pressure, and flow rate.
The control system should be designed to ensure the safe and efficient operation of the plant, and it should be equipped with alarms and emergency shut-off systems to prevent accidents.

Conclusion

The production of 3-chloro-4-methyl-6-phenylpyridazine (CMPP) is an important process in the chemical industry, and it is widely used as an intermediate in the production of various pharmaceuticals, agrochemicals, and other chemical products.
The