Schematic diagram of the preparation of nano-capturing agents (NCs) (A); morphological characterization of NCs (B); pseudovirus neutralization effect of NCs in vitro (C)
Schematic diagram of the preparation of nano-capturing agents (NCs) (A); morphological characterization of NCs (B); pseudovirus neutralization effect of NCs in vitro (C)
National Academy of Sciences It is reported that the current vaccines on the market mainly protect the host from infection by producing neutralizing antibodies on the surface of the S protein
The nano-capturing agent containing hACE2 designed by the research team of Suzhou University can effectively avoid the problem of vaccine failure caused by virus mutation.
In addition, the researchers also added a mucosal adhesion adjuvant, hyaluronic acid, also known as hyaluronic acid, to the nanocapturing agent to extend the residence time of the drug in the lungs, thereby enhancing the effect of suppressing the virus, and Reduce the frequency of administration
In order to significantly improve the stability of the drug during storage and the convenience of transportation, the research team of Suzhou University also introduced the freeze-dried protective agent sucrose to make the nano-trapping agent into a freeze-dried powder texture, so that it can be transported at room temperature.
Related paper information: https://doi.
https://doi.
org/10.
1073/pnas.
2102957118
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