The industrialization of bezoar in vitro

Yesterday, Wuhan Jianmin Dapeng Pharmaceutical Co., Ltd was busy in the in vitro cultivation of bezoar production line in Xin'andu, East and West Lake District In the fermentation workshop, the "steel ox gall" is filled with the flavor of ox yellow Luo Zhanglong, director of pharmaceutical production of Dapeng, Jianmin, Wuhan, said that "steel gall" is full of fresh bovine bile After the introduction of strain fermentation, crystal particles will be precipitated and gradually "grow" into a standard of 3.5cm in diameter to cultivate cattle yellow This year, the sales volume is expected to exceed 2000 kg Bezoar, the gallstone of cattle, is the raw material of many kinds of precious Chinese patent medicines There is only one stone cattle per thousand cattle The annual output of natural bezoar is less than 1 ton, but the demand is more than 200 tons, which is extremely scarce Professor Cai Hongjiao of Tongji Medical College successfully studied the technology of "cultivating bezoar in vitro" in 1993 and obtained the national invention patent The technology simulates the principle and biochemical process of gallstone formation in cattle in vitro and cultivates biological high-quality bezoar The main components of bilirubin are the same as natural bezoar, and the price is only one third of natural bezoar "In vitro cultivation of bezoar" was awarded the national first class certificate of new Chinese medicine in 1997 In 2000, Wuhan Dapeng Pharmaceutical Co., Ltd purchased the technology at a high price It took two years from laboratory to standardized production In 2002, it won the second prize of the National Technological Invention Award (the first prize was vacant) In 2005, Wuhan Jianmin, a listed company, and its joint venture established Jianmin Dapeng Pharmaceutical Co., Ltd to march into Niuhuang industry hand in hand As the only national first-class new Chinese medicine since the founding of new China, the industrialization road of in vitro bezoar has been twists and turns until 2010, the company began to make profits In 2002, in vitro cultivation of bezoar technology won the second prize of National Technological Invention Award (the first prize was vacant) This is another rare and endangered medicine substitute with intellectual property right after the research and issuance of artificial musk and artificial tiger bone by Chinese scientists, which is known as the "milestone" of the modernization of traditional Chinese medicine However, the industrialization of this "golden key" to open the door to the market has been very difficult, which can be described as twists and turns Yu Ping, general manager of Wuhan Jianmin Dapeng Pharmaceutical Co., Ltd., said that since in vitro cultivation of bezoar was a new thing at that time, a series of problems such as intellectual property protection, application scope, quality standard of Chinese patent medicine including in vitro cultivation of bezoar and how to price were all blank in relevant national policies and regulations "These obstacles make industrialization difficult all of a sudden." Yu Ping said it was like seeing a golden mountain, but there was no "ladder" to climb it It was not until 2004 that the state made it clear that cultured bezoar in vitro could be used as natural bezoar "Before that, no manufacturer dared to use your products, and didn't know where to use them." On the market, there is no standard for the determination of the content of bezoar in Chinese patent medicines containing bezoar Jianmin Dapeng decided to "build a ladder" and run for the industry standard After a long-term technical exploration, the company's scientific researchers found that the bilirubin of natural bezoar is combined, the bilirubin of artificial bezoar is free, and the bilirubin of cultivating bezoar in vitro is also combined Through the "scanning" of bilirubin, the true and false of bezoar will be known With the efforts of Jianmin Dapeng and many authoritative organizations, the quality standard improvement of Chinese patent medicine containing bezoar was finally included in the "12th Five Year Plan" of the national pharmacopoeia commission The trickier question is still to come In 1998, after the in vitro cultivation of bezoar was approved by the Ministry of health as a national first-class new drug, it was trial produced in small batch in Wuhan biochemical pharmaceutical factory When Dapeng pharmaceutical bought the intellectual property rights of in vitro cultured bezoar, the biochemical pharmaceutical factory with production license did not stop production "One daughter and two marriages" soon appeared vicious competition The dispute ended in 2009 when Jianmin Dapeng invested tens of millions of yuan to buy up the production and operation rights of the biochemical pharmaceutical factory "More than ten years ago, Professor Cai Hongjiao of Tongji Medical College successfully developed in vitro cultivation of bezoar technology after many years Due to lack of money, the large-scale production of bezoar could not be realized, and almost step Lizhu became a happy follower and went south to Guangzhou." Yu Ping said that through efforts, the government and enterprises finally left the "golden key" in Hubei, and it is expected to go public in three years according to the current development speed.