echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Immunology News > The highest total remission rate is nearly 90%!

    The highest total remission rate is nearly 90%!

    • Last Update: 2021-06-19
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Today, "The Lancet-Oncology" and "The Lancet-Diabetes and Endocrinology" respectively published the importance of the RET inhibitor pralsetinib in the precise treatment of advanced non-small cell lung cancer (NSCLC) and thyroid cancer patients.


    In certain patients with these two major types of cancer, pratinib brings lasting remission and benefits regardless of whether the patient has received other treatments in the past


    One of the researchers, MD Anderson Cancer Center (MD Anderson Cancer Center) Dr.


    "This marks another milestone in the shift to the precision medicine paradigm


    Why is RET targeted therapy attracting attention?

    Why is RET targeted therapy attracting attention?

    Transfection rearrangement (RET) activating fusion and mutation are key drivers of many cancers


    At present, including surgery, radiotherapy, chemotherapy and immunotherapy, standard cancer treatments have limited efficacy for patients with RET fusion-positive solid tumors


    In early clinical trials, some multi-kinase inhibitors with anti-RET activity, including cabozantinib, vandetanib and lenvatinib, have shown certain clinical activity , But has high treatment-related toxicity


    Pratinib is a powerful and highly selective oral precision therapy that targets oncogenic RET mutations (including predictable drug-resistant mutations), which can specifically and powerfully inhibit RET mutations that drive many cancer types


    High response rate in patients with two major cancer types

    High response rate in patients with two major cancer types

    ARROW is a multi-cohort phase 1/2 clinical trial conducted in 71 clinical centers in 13 countries and regions, including China.


    In the NSCLC cohort, a total of 233 patients with RET fusion-positive NSCLC were included in this analysis


    • In patients who have not previously received systemic treatment, pratinib treatment achieved a 70% overall remission rate and 11% complete remission rate


      ▲The median time to remission (A, B) and progression-free survival (C, D) of patients with RET fusion-positive NSCLC


      ▲The median time to remission (A, B) and progression-free survival (C, D) of patients with RET fusion-positive NSCLC


      • Among patients with RET-mutated medullary thyroid cancer: the overall response rate was 71% for those who had not been treated before; among patients who had previously received cabozantinib and/or vandetinib, the overall response rate was 60%


        Among all 142 patients with RET variant thyroid cancer, common (≥10%) grade 3 and above TRAEs include hypertension (24 cases [17%]), neutropenia (19 cases [13%]), Lymphopenia (17 cases [12%]) and anemia (14 cases [10%]); 5 patients (4%) were discontinued due to TRAE, and 1 patient (1%) died due to TRAE


        Benefit more Chinese patients

        Benefit more Chinese patients

        Based on the data previously published by the ARROW study, pratinib has been approved in the United States for the treatment of adult patients with metastatic RET fusion-positive NSCLC, adults with advanced or metastatic RET-mutated medullary thyroid cancer requiring systemic treatment, and adults 12 years and older Pediatric patients, as well as adults with advanced or metastatic RET fusion-positive thyroid cancer and children 12 years and older who require systemic treatment and are refractory to radioiodine (if applicable)


        Pratinib is also the first RET inhibitor approved for marketing in China
        .
        In March of this year, pratinib has been approved for use in adult patients with locally advanced or metastatic NSCLC who have previously received platinum-containing chemotherapy for RET gene fusion positive
        .
        Pratinib's thyroid cancer indication is also expected to accelerate its approval in China.
        It was included in the proposed priority review by the Center for Drug Evaluation (CDE) of the China National Medical Products Administration in April.
        The proposed indication is RET that meets specific conditions.
        Patients with mutant medullary thyroid carcinoma (MTC) patients with RET fusion-positive thyroid cancer
        .

        Note: The original text has been deleted

        Reference

        Reference

        [1] Justin F Gainor, et al.
        , (2021).
        Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study, The Lancet Oncology , DOI: https://doi.
        org/10.
        1016/S1470-2045(21)00247-3

        [1] Justin F Gainor, et al.
        , (2021).
        Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study, The Lancet Oncology , DOI: https://doi.
        org/10.
        1016/S1470-2045(21)00247-3

        [2] Vivek Subbiah, et al.
        , (2021).
        Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW): a multi-cohort, open-label, registrational, phase 1/2 study.
        The Lancet Diabetes & Endocrinology, DOI: https://doi.
        org/10.
        1016/S2213-8587(21)00120-0

        [2] Vivek Subbiah, et al.
        , (2021).
        Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW): a multi-cohort, open-label, registrational, phase 1/2 study.
        The Lancet Diabetes & Endocrinology, DOI: https://doi.
        org/10.
        1016/S2213-8587(21)00120-0

        [3] Targeted therapy pralsetinib safely effectively treats lung and thyroid cancers with RET alterations.
        Retrieved June 10, 2021, from https://

        [3] Targeted therapy pralsetinib safely effectively treats lung and thyroid cancers with RET alterations.
        Retrieved June 10, 2021, from https:// [4] CStone Pharmaceuticals.
        Retrieved June 10, 2021, from https://
    [4] CStone Pharmaceuticals.
    Retrieved June 10, 2021, from https://
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Related Articles

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.