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Recently, a rare childhood disease similar to inflammatory bowel disease was discovered, called "ELF4, X-linked (X-linked) defect", or DEX for short
The results of the study were published in the journal Nature Immunology, entitled "Human auto-inflammatory diseases reveal that ELF4 is a transcriptional regulator of inflammation
The researchers wrote: "Transcription factors that specifically limit the destructive potential of inflammatory immune cells are still unclear
Dr.
The researchers observed that the symptoms experienced by the children participating in the study were similar to those associated with other inflammatory bowel diseases, including ulcerative colitis and Crohn’s disease
After identifying the ELF4 mutation, the researchers studied its role in cultured patient cells and the use of CRISPR gene editing to introduce patient-derived mice with ELF4 mutations
The wide range of effects of this variation suggests that ELF4 and its target genes may play a role in the regulation of inflammation in a variety of diseases, Lucas said
She said: "This gives us the opportunity to identify and study the role of ELF4 and the genes it regulates in immune cell types and inflammatory disease phenotypes
