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The GAS6/AXL inhibitor combination therapy introduced by Sidi Pharmaceuticals was approved for clinical use

 Last Update: 2022-05-21
 Source: Internet
 Author: User

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On April 18, Sidi Medicine announced that its multi-center, open-label Phase 1b/2 clinical trial application for 3D229 injection combined with envolimab injection or lenvatinib in the treatment of advanced solid tumors was approved in China

Screenshot source: CDE official website

Studies have shown that the GAS6-AXL signaling pathway is a key pathway that promotes tumor growth and metastasis, tumor immune escape and drug tolerance

According to the earlier public information of Sidi Medicine, 3D229 (also known as: AVB-500) is the core anti-cancer product of Aravive

This approval is a Phase 1b/2 clinical study in patients with advanced solid tumors of non-small cell lung cancer, clear renal cell carcinoma and urothelial carcinoma, which aims to evaluate the efficacy of 3D229 injection in combination with Envolitinib alone.

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