 Home > Food News > Food Articles > The food nutrition and functional food team of the Institute of Agricultural Products Processing, Chinese Academy of Agricultural Sciences revealed that FIP-nha-fungal immunomodulatory protein induces human gastric cancer

The food nutrition and functional food team of the Institute of Agricultural Products Processing, Chinese Academy of Agricultural Sciences revealed that FIP-nha-fungal immunomodulatory protein induces human gastric cancer

 Last Update: 2022-05-08
 Source: Internet
 Author: User

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Gastric cancer is a common malignant tumor

FIP-nha is a new type of FIP first discovered in the ascomycete Nectria haematococca by gene mining

The results show that FIP-nha can significantly inhibit the proliferation of AGS and SGC7901 in a time- and concentration-dependent manner, but has almost no toxic effect on normal cells; FIP-nha can both promote apoptosis and autophagy in two gastric cancer cells; in-depth Mechanism exploration confirmed that FIP-nha competes with EGF to bind EGFR, thereby reducing the activation effect of EGF on EGFR and its downstream signaling molecules STAT3 and Akt; The cell surface structure of the transmembrane protein EGFR is bound by hydrogen bonds and van der Waals forces

The research was recently published in Food Chemistry: Molecular Sciences (IF 7.

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