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| The first tumor cell protein map drawn |
The first cancer protein interaction map drawn a few days ago covers previously overlooked mutations, and these mutations may become the target of treatment
.
Trey Ideker of the University of California, San Diego, and colleagues completed this map, studying the interaction of dozens of common cancer proteins in breast and head and neck cancers
.
"Cancer genes do not work alone
This map classifies all the different ways in which proteins interact in biological systems
.
In this case, the research team selected 61 common mutant proteins in two cancers and determined how they interact and how they interact with hundreds of other proteins in cancer tumors
"We are looking for protein groups that face mutation pressure during cancer,
" Ideker said
.
For head and neck cancer, the research team found 771 protein interactions, involving approximately 650 proteins, 84% of which have never been reported before
.
If these interactions are critical for tumor growth, then future tumor drugs that target and destroy them may slow cancer growth
At the same time, from the overall data, the team found collagen mutations that were ignored in previous studies
.
"This is a major advancement in the research
Ideker hopes that this method can be used in other cancers, and hopes that more people will join the exploration of mapping cancer protein interactions
.
He said that this will not only help discover new drugs, but will also help scientists discover new cancer biomarkers-which will help doctors design more personalized treatments
Related paper information: https://doi.
https://doi.
org/10.
1126/science.
abf2911 https://doi.
org/10.
1126/science.
abf2911
