The first international analysis of the three-dimensional structure of viral encoded proteins and activators

Tianjin Net News Daily News Reporter Yu Lu It was learned from the international biomedical Joint Research Institute yesterday that in view of the new progress in the research of mers Middle East respiratory syndrome, Rao Zihe, President of the international biomedical Joint Research Institute, and his academician team found that the coronavirus represented by mers virus has the coding correction function close to that of higher organisms, and has resolved the three-dimensional structure of the protein encoded by the virus and the activator for the first time in the world It provides a key biological basis for further screening and design of antiviral drugs The person in charge said that since the emergence of mers virus in the Middle East, it has caused thousands of infections around the world Especially in the past few months, there has been a mers epidemic characterized by hospital transmission in South Korea, which poses a serious threat to the prevention and control of infectious diseases in China In view of the major new outbreak of coronavirus, Rao Zihe and his team further focused on the functional mechanism of replication core protein of coronavirus Coronavirus is the largest RNA virus in the genome In order to prevent the error of replication process, mers and other coronaviruses have evolved a coding correction function close to that of higher organisms, and nsp14 protein encoded by the virus is responsible for this process According to the unique biological characteristics of this coronavirus, Rao Zihe's research team has analyzed the three-dimensional structure of nsp14 and Nsp10 complex for the first time in the world, and clarified the molecular mechanism of the coding correction function At the same time, the important functions of nsp14-nsp10 provide a key biological basis for further screening and design of antiviral drugs In addition, Rao Zihe and his team have made important progress in the study of Ebola virus In the process of replication, Ebola virus needs to encode a unique nuclear protein Rao Zihe's research team focused on the high-resolution structure of nuclear protein core domain 1.8, providing intuitive and accurate information for the replication and assembly of Ebola virus.