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The first domestic product!

 Last Update: 2021-12-25
 Source: Internet
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Article source: Medical Rubik's Cube Info

On December 21, the CDE official website indicated that the listing application of Roche vedotin for injection (Polatuzumab vedotin) is planned to be included in the priority review for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL)

Vibotuzumab is a first-in-class anti-CD79b ADC, which is composed of CD79 targeting monoclonal antibody Polatuzumab, cleavable linker and small molecule drugs

Vibotuzumab mechanism of action

Vibotuzumab was first approved by the FDA in June 2019 (trade name: Polivy), combined with bendamustine + Rituxan (rituximab) for the treatment of relapse or refractory that has received at least two previous treatments Adult patients with curative (R/R) diffuse large B-cell lymphoma (DLBCL)

A previous phase Ib/II clinical trial of Vibotuzumab evaluated the efficacy of the drug in 80 patients with relapsed or refractory DLBCL

In August of this year, the pivotal Phase III POLARIX trial of Vibotuzumab combined with R-CHP for the first-line treatment of DLBCL reached its primary endpoint

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The first domestic product!

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