-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
The screenshot of the mouse brain metabolome map data shows that with age, the distribution of adenosine in the brain area
.
These resources will help other scientists interpret research results and conduct new research
A team led by researchers from the University of California, Davis published the first map of metabolites in the mouse brain
.
The data set includes 1,547 different molecules in 10 brain regions of male and female mice in the laboratory, from adolescence to adulthood to old age
"This is the largest metabolome analysis of the brain in the world
.
It covers 1,547 confirmed metabolites and can analyze the many chemical transformations of energy, neurotransmitters, or complex lipids in the brain," University of California, David Said Professor Oliver Finn, director of the West Coast Metabolomics Center of the Sri Lanka Genome Center and senior author of the paper
Metabolomics is the study of chemical fingerprints of living cell metabolism
.
It uses advanced high-throughput technology to separate and identify all the different chemical substances or metabolites present in cells, tissues or organs at a given time
Postdoctoral fellows Jun Ding, Fiehn and his colleagues sampled mice at 3 weeks (adolescence), 16 weeks (early adulthood), 59 weeks (middle-aged), and 92 weeks (old age)
.
They observed 10 brain regions with different functions
Fiehn said that the results of the study show that the brain metabolome is significantly different from large areas of the brain, such as the brainstem that controls important functions such as breathing and blood pressure, and the brain that controls movement, language, and thinking
.
In addition, specific sections show high concentrations of metabolites associated with specific receptors, such as adenosine, ceramide, and phospholipid ether
They did not find any significant metabolic differences in the brains of male and female mice
.
Metabolites of the aging brain
When the research team compared animals of different ages, they found that, overall, the differences in metabolism between parts of the adult mouse brain were the largest
.
Differences between different regions are relatively small during adolescence, and smaller at older ages
"At a very old age, the energy function seems to be less effective, and the myelin sheath surrounding the axon or brain circuit changes its composition," Fiehn said
.
Lipid molecules show great differences between different ages and different brain regions
.
These lipids deserve special research to understand their relationship with changes in brain function (such as signal transduction)
He said that at a very old age, the response system against oxidative stress becomes very active, and proteins begin to break down into peptides at a faster rate
.
These changes are reflected in the metabolome
.
This work was carried out in collaboration with the Mouse Biology Project at the University of California, Davis, which was led by Professor Kent Lloyd
.
"This landmark paper clearly demonstrates the power of laboratory mice as models to accelerate our understanding of brain metabolism, including humans in particular," Lloyd said
.
Nature Communications
DOI
10.
1038/s41467-021-26310-y
###
