The fertility hope of gynecological cancer patients, you need to know these

In recent years, with the younger age of onset of malignant tumors and the general postponement of the reproductive age of women, fertility protection has become a difficult problem that often needs to be weighed and solved when clinically formulating treatment plans for cancer patients

A few days ago, the series of activities of the female reproductive tract infection and cervical cancer prevention and empowerment project (Fuzhou Station) and the tumor fertility seminar were successfully held

Professor Huang Hefeng

Academician of Chinese Academy of Sciences

Obstetrics and Gynecology Hospital Affiliated to Fudan University

"With the continuous development of the concept of value medicine and the continuous progress of individualized tumor medicine, how to protect the fertility of patients as much as possible on the premise of ensuring the effect of tumor treatment has become an important issue in clinical work

Needs that cannot be ignored:

How to balance tumor treatment and fertility protection?

According to statistics, although the incidence of most gynecological malignancies peaks after the age of 50, a high proportion of women are still diagnosed with gynecological cancers during their reproductive years, and newly diagnosed endometrial, ovarian and cervical cancers under the age of 45.

However, a large proportion of patients with gynecologic malignancies have fertility preservation needs

Due to the lack of patients' own awareness of fertility risks and the lack of attention to fertility issues, the lack of access to adequate fertility protection information, and the fact that many patients are ashamed to express their fertility needs and are understood to have no desire to bear children, resulting in a large number of fertility Conservation needs are not being met

Professor Wei Lihui

Peking University People's Hospital

"Resection of diseased reproductive organs, chemotherapy or pelvic radiotherapy are currently the main treatment measures for gynecological malignancies

Basic principles of fertility protection for cancer patients

A pooled analysis of treatment data from 3,044 patients from 65 studies showed that women with early-stage cervical cancer had an average live birth rate of 67.

The 5-year survival rate of patients with early-stage ovarian cancer after fertility-sparing surgery is 83% to 100%, and the number of live births is also increasing, and most of them are spontaneous pregnancies

Commonly used reproductive assistive techniques in patients with other malignant gynecological tumors

The "mirror" that reflects fertility:

AMH guides individualized fertility protection strategies

"Before the patient makes a decision to preserve fertility, it is recommended to evaluate the ovarian reserve function

Summary flow chart of maternity protection decision after diagnosis of malignant gynecological tumor

Ovarian reserve refers to the ability of the ovaries to provide fertilized eggs for a healthy and successful pregnancy

Comparison of characteristics of commonly used markers of ovarian reserve

A 5-year follow-up study to assess the relationship between ovarian function and markers of pretreatment hormones and ovarian reserve showed that, among pretreatment serum AMH, FSH, AFC, and age were included in univariate analysis to predict later ovarian activity, only AMH was found in multivariable logistic regression.