The fecal transplant allowed premature mice to live longer

bacteria that are isolated from human feces.some relationships are fleeting, but others last a lifetime, such as the mutually beneficial relationship between a person and trillions of bacteria in his gut. But when a person grows older with microbes in the body, the situation may be abnormal. Now, a new study in mice suggests that aging actually alters the microbiome, and in some cases, fecal transplants fix the problem.
fecal microbiome transplantation is not a new treatment, and the earliest known records date back to the 4th century A.D. in China, when a doctor named Ge Hong told patients that diarrhea could be treated by eating fresh faeces from healthy people. Recent clinical trials have shown that dung transplants are an effective way to treat stubborn Clostridium difficile infections, and they are also trying to use it to treat inflammatory bowel disease and constipation.
, a biologist at the University of Oviedo in Spain, and colleagues found that aging and age-related diseases often go hand in hand with intestinal disorders because the balance between multiple bacteria in the gut is disrupted. So they decided to test the microbiome in five children with premature aging. Premature aging is a genetic disease that causes premature aging and death. They also studied the microbiome of more than a dozen mice, all genetically modified to show similar symptoms.
with the development of the disease, sick children and mice have become more and more serious intestinal disorders. But the researchers found no signs of abnormality in the group of 17 centenarians, who were thought to have "successfully" aged. Instead, these centenarians have a healthy microbiome, many of which come from wart microbugs.
, the researchers wanted to know if changing the microbiome in mice with early aging would affect the progression of their disease. They extracted bacteria from the faeces of healthy mice and implanted them in the intestines of sick mice. After a few weeks, the development of symptoms in mice with early aging began to slow down, with slower weight loss and no hypoglycemia in mice of the same age, two common symptoms of early aging. In a recent report published in Nature Medicine, the team reported that the average life expectancy of the treated mice was nearly 15 percent longer than that of the un treated mice (160 days for the former and 141 days for the latter).
possibility of extending life in the "Technology" trial is surprising. Barcena, who is now a postdoctoral student at the Wellcome Sanger Institute in the UK, said. (Source: Jin Nan, China Science Journal)
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