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News from March 11, 2021 // - In response to brain injury, neural stem cells will aggregate and migrate to the site of injury.
The FASEB Journal
In the article, researchers discovered for the first time that metalloproteinase-2 (MMP2) secreted by endothelial cells may induce cell damage response processes.
Image source: Pixabay/CC0 Public Domain
Researcher Rita Matta said that we are very interested in studying the mechanism that induces this aggregation effect of neural stem cells.
In particular, the researchers found that the secretion of MMP2 activates a protein called N-cadherin, which can act as a cell adhesion agent; this process leads to arm-shaped neural stem cells.
Previously, researchers developed polyethylene glycol magnetic beads to transport neural stem cells and endothelial cells to treat brain damage; researcher Gonzalez said that by creating a technology that can be simulated in human brain tissue, we can better understand the human body Neurological processes, and use the same tools to develop therapeutic strategies to repair damaged or impaired tissues; the latest research provides very valuable information for the development of this new technology.
Finally, the researchers stated that the more we know about the process by which endothelial cells affect neural stem cells, the more we can develop new delivery vehicles in the encapsulated magnetic beads.
Original source:
Original source:Rita Matta, Muhammad Sulaiman Yousafzai, Michael Murrell, et al.
Rita Matta, Muhammad Sulaiman Yousafzai, Michael Murrell, et al.
onlinelibrary.
wiley.
com/doi/10.
1096/fj.
202002302RR">Endothelial cell secreted metalloproteinase-2 enhances neural stem cell N-cadherin expression, clustering, and migration , The FASEB Journal (2021).
DOI:10.
1096/fj.
202002302RR onlinelibrary.
wiley.
com/doi/10.
1096/fj.
202002302RR">Endothelial cell secreted metalloproteinase-2 enhances neural stem cell N-cadherin expression, clustering, and migration The FASEB Journal
