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This study provides further evidence that the neighborhood environment affects neurodegeneration and cognitive decline.
Everyone has heard the story of "Mengmu's Three Moves", right? The three migrations of Meng Ke's mother means that Meng Ke's mother moved many times in order to choose a good environment to educate her children.
"
San Zi Jing" said: "Ximeng mother, choose a neighbor.
"Meng's mother's third migration came from here.
The words interpret the message as Mencius’s mother took great pains to make her children have a truly good educational environment.
They moved to three places, and now they are sometimes used to refer to their parents’ good intentions.
Recently, scientists have developed a deep interest in the cognition of the environmental impact of the neighborhood.
First of all, a study published on JAMA Network Open last year showed that compared with children from affluent communities, children from poor communities perform poorly in a range of cognitive functions such as language ability, reading skills, memory and attention.
The brain capacity in key cognitive areas is also smaller.
Subsequently, the researchers focused on the elderly whose activities are mainly near their homes.
For example, there have been studies in Australia aimed at investigating the longitudinal association between the objective and perceived neighbourhood environment and neighbourhood leisure walking.
It is found that the factors that affect local leisure hiking are: medium or large parks, beach accessibility, and better street connectivity (decreased after adjusting neighborhood awareness).
And every time a subjectively recognized neighborhood attribute is added, leisure walking increases by 9 min/week (increased frequency by 12%).
The above studies have provided more powerful evidence for urban planners and policy makers, proving that neighborhoods with good street connectivity and the existence of various scale parks nearby are beneficial to local residents' leisure walking and health.
So, does the neighborhood environment affect the cognitive decline of the elderly without neurodegeneration? To this end, an expert in the field of brain science at the University of Wisconsin has given the answer in a study recently published in the journal Neurology.
The longitudinal study included a total of 601 participants with unimpaired cognitive abilities (average baseline age = 59 years), the latter from the Alzheimer's Disease Prevention Research Registry in Wisconsin and Alzheimer's in Wisconsin The clinical cohort of the AD Research Center.
Dynamically collect participant MRI and cognitive test data.
Geocode the participant’s place of residence and rank it according to the environmental situation relative to the state of residence.
A linear regression model was fitted to test the association between the level of the neighborhood environment and the longitudinal changes in the thickness of the cerebral cortex and cognitive test performance.
The mediation test is used to assess whether neurodegeneration and cognitive decline are related to the neighborhood environment.
Among the middle-aged and elderly study population, participants who live in the worst 1/5 community (N=19) are closely related to the thinning of the cortex in the hallmark area of AD and the decline of preclinical AD cognitive ability, especially The performance is particularly poor in the Trails-Making test, but the decline in the Rey auditory and speech learning test or the delayed recall subtest of story memory is not obvious.
Further, after controlling for the racial and demographic differences between neighborhood-level disadvantaged groups, the above correlations are still significant.
The results of mediation analysis showed that cortex thinning partially mediates the relationship between the neighborhood environment and cognitive decline.
It can be seen that living in the most disadvantaged neighborhood is related to the accelerated deterioration of AD's hallmark brain area and cognitive decline.
In summary, this study provides further evidence that the neighborhood environment affects neurodegeneration and cognitive decline.
Reference: Association of Neighborhood Context, Cognitive Decline, and Cortical Change in an Unimpaired Cohort.
https://doi.
org/10.
1212/WNL.
0000000000011918
Everyone has heard the story of "Mengmu's Three Moves", right? The three migrations of Meng Ke's mother means that Meng Ke's mother moved many times in order to choose a good environment to educate her children.
"
San Zi Jing" said: "Ximeng mother, choose a neighbor.
"Meng's mother's third migration came from here.
The words interpret the message as Mencius’s mother took great pains to make her children have a truly good educational environment.
They moved to three places, and now they are sometimes used to refer to their parents’ good intentions.
Recently, scientists have developed a deep interest in the cognition of the environmental impact of the neighborhood.
First of all, a study published on JAMA Network Open last year showed that compared with children from affluent communities, children from poor communities perform poorly in a range of cognitive functions such as language ability, reading skills, memory and attention.
The brain capacity in key cognitive areas is also smaller.
Subsequently, the researchers focused on the elderly whose activities are mainly near their homes.
For example, there have been studies in Australia aimed at investigating the longitudinal association between the objective and perceived neighbourhood environment and neighbourhood leisure walking.
It is found that the factors that affect local leisure hiking are: medium or large parks, beach accessibility, and better street connectivity (decreased after adjusting neighborhood awareness).
And every time a subjectively recognized neighborhood attribute is added, leisure walking increases by 9 min/week (increased frequency by 12%).
The above studies have provided more powerful evidence for urban planners and policy makers, proving that neighborhoods with good street connectivity and the existence of various scale parks nearby are beneficial to local residents' leisure walking and health.
So, does the neighborhood environment affect the cognitive decline of the elderly without neurodegeneration? To this end, an expert in the field of brain science at the University of Wisconsin has given the answer in a study recently published in the journal Neurology.
The longitudinal study included a total of 601 participants with unimpaired cognitive abilities (average baseline age = 59 years), the latter from the Alzheimer's Disease Prevention Research Registry in Wisconsin and Alzheimer's in Wisconsin The clinical cohort of the AD Research Center.
Dynamically collect participant MRI and cognitive test data.
Geocode the participant’s place of residence and rank it according to the environmental situation relative to the state of residence.
A linear regression model was fitted to test the association between the level of the neighborhood environment and the longitudinal changes in the thickness of the cerebral cortex and cognitive test performance.
The mediation test is used to assess whether neurodegeneration and cognitive decline are related to the neighborhood environment.
Among the middle-aged and elderly study population, participants who live in the worst 1/5 community (N=19) are closely related to the thinning of the cortex in the hallmark area of AD and the decline of preclinical AD cognitive ability, especially The performance is particularly poor in the Trails-Making test, but the decline in the Rey auditory and speech learning test or the delayed recall subtest of story memory is not obvious.
Further, after controlling for the racial and demographic differences between neighborhood-level disadvantaged groups, the above correlations are still significant.
The results of mediation analysis showed that cortex thinning partially mediates the relationship between the neighborhood environment and cognitive decline.
It can be seen that living in the most disadvantaged neighborhood is related to the accelerated deterioration of AD's hallmark brain area and cognitive decline.
In summary, this study provides further evidence that the neighborhood environment affects neurodegeneration and cognitive decline.
Reference: Association of Neighborhood Context, Cognitive Decline, and Cortical Change in an Unimpaired Cohort.
https://doi.
org/10.
1212/WNL.
0000000000011918
