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Scientists have discovered a new family of beneficial proteins in the lungs, a discovery that could pave the way for new treatment options for patients with respiratory failure
For the first time, researchers at Anglo Ruskin University have identified common tongue receptors for bitter taste, called T2Rs, which are also found in the blood vessels of the lungs
More than 10% of the world's intensive care unit patients suffer from acute respiratory distress syndrome (ARDS), with a mortality rate approaching 40%
ARDS is associated with an excessive increase in pulmonary vascular permeability, which allows proteins and fluids to enter the lungs, leading to pulmonary edema, commonly referred to as "water on the lungs"
The researchers found that phenylthioaminoamine and denatonium -- the most bitter known substance -- act on the bitter taste receptors T2R38 and T2R10, respectively
Senior author Havovi Chichger, Ph.
"In this new study, we discovered a new family of proteins called T2Rs, or bitter taste receptors, in the blood vessels of the lungs
"Most interestingly, when we stimulated these proteins, we found that they provided protection against fluid leakage
