The development of traditional Chinese medicine needs the support of modern science and technology

The modernization of traditional Chinese medicine is the process of combining the advantages and characteristics of traditional Chinese medicine with modern science and technology, and pushing traditional Chinese medicine to modernization and internationalization Our research group encountered many problems in the series of research on the treatment of coronary heart disease with Scallion extract, which were solved by means of modern science and technology, and fully realized the important role of modern science and technology in the modernization of traditional Chinese medicine Several key links use modern technology to extract the effective components In the early stage of the research group, the experiment of the treatment of acute myocardial ischemia with Congbai, a traditional Chinese medicine of xinwentongyang, has proved that Congbai extract has a good role in expanding coronary artery and improving myocardial ischemia Organic sulfur compounds are the main active components of Allium plants, but because of their unstable physical and chemical properties, volatile and decomposition, the results of traditional methods are not ideal, so we use supercritical CO2 fluid extraction technology to extract the effective components of Allium Supercritical CO2 fluid extraction technology is a new extraction and separation technology, which is especially suitable for the extraction and separation of unstable substances Compared with the traditional steam distillation method, it has incomparable advantages in the extraction of volatile oil It overcomes the shortage of extraction time, high operating temperature, low extraction efficiency and easy to destroy some components sensitive to humidity and heat Sink Because the non-toxic CO2 is used as the solvent in the extraction process, and there is no residual solvent in the product, so the product is natural, safe, and reproduce the original flavor of raw materials, which is an ideal method for extracting natural products It has been proved that supercritical CO2 extraction technology is feasible and the best technological condition for the extraction of fat soluble components from onion With the help of supercritical CO2 fluid extraction technology, we have developed a preparation of scallion extract - Boxin Tong At present, the batch number of the provincial food and drug administration has been widely used in clinical as the hospital preparation Based on the successful development of boxiton, it is urgent for us to develop a convenient and effective dosage form for patients with acute myocardial infarction Nano traditional Chinese medicine is a general term for some traditional Chinese medicine after being nano-sized It refers to the effective components, effective parts, original drugs and their compound preparations of traditional Chinese medicine with the particle size less than 100 nm manufactured by using nano technology After the drug is nano encapsulated, a relatively closed environment is formed, which can effectively prevent the decrease of drug stability caused by external factors, so as to increase the chemical stability of the drug; on the other hand, it can increase the biological stability of the drug, especially the destruction of various acid-base environments and enzymes in the digestive tract and blood, and the nano drug carrier system can be affected by the carrier The presence of the drug transports the drug relatively completely to the site of action The experiment confirmed that the onion white extract nano emulsion spray can be used through sublingual administration to facilitate the use of clinical emergency patients The quality control of traditional Chinese medicine is restricted by the factors of producing area, growing environment, harvest season, soil and climate, which makes the quality of traditional Chinese medicine difficult to control The quality control of traditional Chinese medicine often becomes the bottleneck of the modernization of traditional Chinese medicine In order to select the best raw material of scallion preparation, we spent more than two years and traveled more than 30000 kilometers We investigated and collected 122 samples of scallion from all over the country (except Hong Kong, Macao, Taiwan and Tibet), and studied the genetic diversity of Scallion by using the technology of genetic diversity analysis (RAPD), and determined the best varieties of scallion API Through the determination of element content of scallion from different places, we searched for the best varieties of scallion To find the best origin of medicinal materials, and finally establish a production base of ten thousand mu of shallot in Huangpi area of Wuhan It is inevitable for the development of the modernization of traditional Chinese medicine to combine multiple disciplines At present, many high-tech and modern methods have been gradually applied in the research of the modernization of traditional Chinese medicine, which to a certain extent promotes the process of the modernization of traditional Chinese medicine Through the research process of scallion extract, we found that modern technology research goes deep into many aspects, such as drug extraction process, dosage form improvement and quality control, but at the same time, we also realized that the depth and scope of modern technology applied to the research of traditional Chinese medicine is far from enough The modernization of traditional Chinese medicine is a long process, which needs not only the interdisciplinary development, but also the research accumulation of scholars of all ages Only on the basis of following the essence of traditional Chinese medicine theory and inheriting the clinical characteristics of traditional Chinese medicine, combining with modern academic thoughts and scientific culture, absorbing, drawing on and using the achievements of modern scientific development and high-tech means, reforming traditional products according to internationally recognized standards and norms, and taking the road of modernization of traditional Chinese medicine, can the development of traditional Chinese medicine create and present with traditional characteristics The traditional Chinese medicine preparation which adapts to the progress of pharmaceutical technology will lay a solid foundation for the traditional Chinese medicine preparation to step out of the country, go to the world and participate in the international competition with a new look.