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    Home > Medical News > Medical Science News > The development of a new mouse model at Shanghai Zoda will help to study mental disorders caused by natural disasters

    The development of a new mouse model at Shanghai Zoda will help to study mental disorders caused by natural disasters

    • Last Update: 2020-12-14
    • Source: Internet
    • Author: User
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    such as earthquakes will not only bring heavy casualties, but also affect people's mental health. The study was published in the journal Scientific reports
    The New York Times. The team from Shanghai Jiaoba University noted that survivors of natural disasters such as severe earthquakes are susceptible to mental disorders such as acute stress disorder (ASD), post-traumatic stress disorder (PTSD), depression, etc. As a result, the team successfully modeled a new type of depressed mouse with 24-hour claustrophobia by simulating the state in which earthquake survivors were trapped in buildings and unable to move freely. They then observed the short-term and long-term effects of constraints 2 and 35 days later, respectively.
    , mice showed similar depressive behavior 35 days after the binding, with the brain absorbing less glucose and slowing the development of the adult hema's nervous system. They also analyzed expression spectrum differences based on microarray analysis, and found that genes and channels associated with depression and other mental illnesses were expressed differently in the forehead (PFC) and hippocupral bodies. Not only that, but this type of depression caused by 24-hour restraint can be reversed under the antidepressant fluoxetine.
    findings suggest that a severe stress event can lead to long-term depression-like espresso. In addition, these 24-hour constrained stress mice could also be used in future mood disorder studies.
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