The cover of "Science" is heavy!

The rockfish living on the coast of the Pacific Ocean hides a mystery about longevity: Among 137 species of rockfish, there are huge differences in lifespan between different species-some can only live for about 10 years, some But they can live for 200 years, and the life span of the two is 20 times worse! This also makes the latter one of the longest-lived vertebrates

What is it that brings amazing longevity? Today's latest issue of "Science" magazine reveals to us the mystery behind this longevity in the form of a cover paper

Scientists from the University of California, Berkeley collected tissue samples of 88 species of rockfish, and did whole-genome sequencing to analyze whether there are some genetic differences between rockfish of different life spans

First of all, the long-lived rock fish (lives more than 105 years) has abundant DNA repair pathways

Consistent with this discovery, those short-lived rockfish (less than 20 years alive) do not have these abundant pathways

In addition to the DNA repair pathway, the researchers also found 137 genes related to longevity, which affect insulin signaling, body shape, and adaptation to the environment

This finding is also in line with the current longevity theory

More importantly, the researchers pointed out that if you want to live longer, you can't just look at your genes, but also your environment

Therefore, these long-lived fish can safely reduce the inflammatory response in the body, and their DNA repair pathway can play a more critical role

"Science" magazine has a high evaluation of this research

▲Humans can learn a lot from the longevity rock fish (picture source: reference [3])

For example, we can improve the activity of DNA repair pathways and reduce the occurrence of cancer; for example, we can reduce the body’s inflammatory response under appropriate circumstances, thereby reducing the burden on the body; finally, we must build a good living environment and support Develop good living habits and reduce premature deaths

Note: The original text has been deleted

Reference materials:

[1] Sree Rohit Raj Kolora et al.

[2] J.

[3] Pacific Ocean rockfish genomes reveal genetic drivers of extreme life span, Retrieved November 11, 2021, from https:// Genome comparison of 88 rockfish species pinpoints genes associated with a long lifespan, Retrieved November 11, 2021, from https://phys.