The correlative clotting disorder and micro blood clot formation in patients with COVID-19 developed in patients with glioma.

The spread of new coronavirus disease (COVID-19) in 2019 increased infection and mortality rates in tumor patients and was closely related to the increase in the incidence of high coagulation and cerebrovascular disease.
, however, the effects of COVID-19-related clotting disorders on tumor biology are unclear.
The Matthew Pun, a medical science specialist training program at the University of Michigan School of Medicine in the United States, and others reported in Acta Neurologica in June 2020 that a case of thalesta-high-level glioma was associated with COVID-19-related clotting disorder in patients with extensive micro blood clot formation in the tumor.
21-year-old female patients with headaches, blurred vision and vomiting.
the nervous system did not see positive signs, considered for tension headache.
2 months, fainting appeared, the skull CT prompted the screen on the cerial brain occupied (up to 4.3cm diameter), accompanied by obstructive hydrocephalus.
followed by cerebral palsy and emergency brain draination.
postoperative review of the skull CT and MRI both suggested that the brain's outdoor drainage tube was in good position, but the tumor and the brain chamber hemorrhage were significant and transparently shifted (Figures 1a and b).
results showed that patients with nasopharyngeal swabs tested positive for SARS-CoV-2 and showed typical COVID-19-associated clotting disorders, including a sustained increase in D-djubo levels (Figure 1c), with no change in PT or APTT.
patients with no respiratory symptoms and no abnormalities in the chest.
biopsy confirmed high-level glioma (Figure 1d), positive glioblastose acid protein (GFAP) (Figure 1f), H3K27me3 expression loss, Ki-67 high expression.
addition, line PTAH staining found that the tumor emits more blood, in-blood thrombosis, accompanied by microthrombosis and fibrin deposition and macrophage immersion (Figure 1g-l).
tumor and the gap around the blood vessels can be seen macrophage immersion (Figure 1m-n) and a small amount of CD4-positive T cell immersion (Figure 1o).
1. a. Skull MRI and b. Cranial CT axial imaging suggests pasaliae placeholder lesions, midline shift (white arrow indicates bleeding).
c. Measure D-D-djumer levels for 2 consecutive days (the dashed line is the upper limit of the reference value).
d.H.amp;E staining is visible to polyformed tumor cells.
e and f. immunogroup staining visible tumor cell expression GFAP(e) and H3K27M(f).
g-i. The H&E stain can be seen in the blood vessels polythrombosis accompanied by bleeding (black arrow), asterisks indicate amorphous acidophilus fibrin deposition, and large black arrows indicate macrophages.
j-l. PTAH staining is visible in endovascular fibrin deposition and macrophages.
m-o. CD163 immunoglomeration staining in the real part of the tumor and the gap between macrophages and CD4-positive T-cells in the inner part of the tumor and around the blood vessels.
The case shows that COVID-19-associated clotting disorders may affect tumor biology behavior and disease progression in a new way, and the specific mechanisms need to be studied.
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