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New progress has been made
in the study of the protective effect and mechanism of jackfruit polysaccharides on the intestinal immune barrier and liver in rats with high fat-induced obesity.
The research team studied the protective effect and mechanism
of jackfruit polysaccharides on obesity-induced colonic oxidative damage and liver damage through a rat model of high-fat induced obesity.
The results showed that jackfruit polysaccharides could repair intestinal mucosal damage to improve the barrier function of mucosa.
and relieve inflammation and lipid accumulation in liver tissue, exerting a protective effect
on the liver of obese rats.
This study provides an important theoretical reference
for the next research and development of functional polysaccharide products for characteristic tropical crops.
in the study of the protective effect and mechanism of jackfruit polysaccharides on the intestinal immune barrier and liver in rats with high fat-induced obesity.
The research team studied the protective effect and mechanism
of jackfruit polysaccharides on obesity-induced colonic oxidative damage and liver damage through a rat model of high-fat induced obesity.
The results showed that jackfruit polysaccharides could repair intestinal mucosal damage to improve the barrier function of mucosa.
and relieve inflammation and lipid accumulation in liver tissue, exerting a protective effect
on the liver of obese rats.
This study provides an important theoretical reference
for the next research and development of functional polysaccharide products for characteristic tropical crops.
Obesity is one of the biggest public health challenges facing the world today, and it is also a major problem
for public health in our country.
The latest research has found that active polysaccharides, as a class of functional substances, not only have immunomodulatory functions, but also mediate glycolipid metabolism by regulating ATGL-(PPAR-α), (SREBP-1c)-ACC/FAS and ACC-CPT1, and play an important role
in maintaining the function and health of cells and tissues 。 In recent years, the research team of the Institute of Fragrant Beverages of the Chinese Academy of Thermal Sciences has systematically studied the antioxidant activity, immune regulation, gastrointestinal digestion and absorption and intestinal flora adjustment of functional polysaccharides in agricultural products, focusing on the key scientific issues of the mining and utilization of functional functional factors of tropical crops, taking jackfruit, bitter tea and other crops as the research objects, laying a theoretical foundation
for the high-value development and utilization of tropical agricultural products.
for public health in our country.
The latest research has found that active polysaccharides, as a class of functional substances, not only have immunomodulatory functions, but also mediate glycolipid metabolism by regulating ATGL-(PPAR-α), (SREBP-1c)-ACC/FAS and ACC-CPT1, and play an important role
in maintaining the function and health of cells and tissues 。 In recent years, the research team of the Institute of Fragrant Beverages of the Chinese Academy of Thermal Sciences has systematically studied the antioxidant activity, immune regulation, gastrointestinal digestion and absorption and intestinal flora adjustment of functional polysaccharides in agricultural products, focusing on the key scientific issues of the mining and utilization of functional functional factors of tropical crops, taking jackfruit, bitter tea and other crops as the research objects, laying a theoretical foundation
for the high-value development and utilization of tropical agricultural products.
The protective effect and mechanism
of jackfruit polysaccharide on the intestinal immune barrier and liver of high-fat-induced obesity rats was studied through a high-fat-induced obesity rat model.
The results showed that jackfruit polysaccharides could improve colonic oxidative damage, inhibit small intestinal glucose transport to lower blood sugar, repair intestinal mucosal damage to improve mucosal barrier function, downregulate the expression of inflammatory genes TNF-α and IL-6, upregulate the expression of short-chain fatty acid receptor genes GPR43 and GPR41 and the tight junction protein Occludin, and enhance the intestinal immune barrier function and mechanical barrier function.
It also significantly improved the blood lipid indexes of obese rats, alleviated inflammation and lipid accumulation in liver tissue, activated the lipolysis pathway (PPARα/PPARγ-LPL/HSL-CPT1) and the β oxidation pathway of fatty acids (PPARα/PPARγ-CPT1), inhibited the AMPK-mediated fat synthesis pathway (AMPK/(SREBP-1c)-ACC-FAS), and promoted the expression of free fatty acid receptor genes (GPR43, GPR41).
It intervenes in the expression of thermogenic gene (UCP2), regulates lipid metabolism in liver and liver adipose tissue, and has the effect of
protecting the liver of obese rats.
of jackfruit polysaccharide on the intestinal immune barrier and liver of high-fat-induced obesity rats was studied through a high-fat-induced obesity rat model.
The results showed that jackfruit polysaccharides could improve colonic oxidative damage, inhibit small intestinal glucose transport to lower blood sugar, repair intestinal mucosal damage to improve mucosal barrier function, downregulate the expression of inflammatory genes TNF-α and IL-6, upregulate the expression of short-chain fatty acid receptor genes GPR43 and GPR41 and the tight junction protein Occludin, and enhance the intestinal immune barrier function and mechanical barrier function.
It also significantly improved the blood lipid indexes of obese rats, alleviated inflammation and lipid accumulation in liver tissue, activated the lipolysis pathway (PPARα/PPARγ-LPL/HSL-CPT1) and the β oxidation pathway of fatty acids (PPARα/PPARγ-CPT1), inhibited the AMPK-mediated fat synthesis pathway (AMPK/(SREBP-1c)-ACC-FAS), and promoted the expression of free fatty acid receptor genes (GPR43, GPR41).
It intervenes in the expression of thermogenic gene (UCP2), regulates lipid metabolism in liver and liver adipose tissue, and has the effect of
protecting the liver of obese rats.
The findings were published in Frontiers in the title "Polysaccharides from Artocarpus heterophyllus Lam.
(jackfruit) pulp improves intestinal barrier functions of high fat diet-induced obese rats.
" Nutrition》
。 Zeng Shunjiang, a master of the Institute of Fragrant Beverages of the Chinese Academy of Thermal Sciences and Hainan University, and Associate Professor Cao Jun of Hainan University are the co-first authors of the paper, and Associate Researcher Zhu Xue and researcher Tan Lehe of the Institute of Aromatic Beverages of the Chinese Academy of Thermal Sciences are the corresponding authors of the paper.
Titled "Protective effects of polysaccharide from Artocarpus heterophyllus Lam.
(jackfruit) pulp on non-alcoholic fatty liver disease in high-fat diet rats via PPAR and AMPK signaling pathways" Published in Journal of Functional Foods
.
Zeng Shunjiang, a master of cultivation from Hainan University, is the first author of the paper, and Zhu Xue, associate researcher of the Institute of Aromatic Beverages of China Academy of Thermal Sciences, and Associate Professor Cao Jun of Hainan University are the corresponding authors
of the paper 。 This research relies on the Hainan Provincial Key Laboratory of Suitability Processing and Quality Control of Characteristic Tropical Crops, supported by the team members of the Processing and Engineering Technology Research Office of the Institute of Fragrant Beverages/Tropical Woody Grain Research Center of the Chinese Academy of Thermal Sciences, and won the National Natural Science Foundation of China Youth Science Foundation Project (No.
31901649) and the special 2022 science and technology "unveiling" project of the basic scientific research business fund of the academy (No.
1630142022009) Funding
.
(jackfruit) pulp improves intestinal barrier functions of high fat diet-induced obese rats.
" Nutrition》
。 Zeng Shunjiang, a master of the Institute of Fragrant Beverages of the Chinese Academy of Thermal Sciences and Hainan University, and Associate Professor Cao Jun of Hainan University are the co-first authors of the paper, and Associate Researcher Zhu Xue and researcher Tan Lehe of the Institute of Aromatic Beverages of the Chinese Academy of Thermal Sciences are the corresponding authors of the paper.
Titled "Protective effects of polysaccharide from Artocarpus heterophyllus Lam.
(jackfruit) pulp on non-alcoholic fatty liver disease in high-fat diet rats via PPAR and AMPK signaling pathways" Published in Journal of Functional Foods
.
Zeng Shunjiang, a master of cultivation from Hainan University, is the first author of the paper, and Zhu Xue, associate researcher of the Institute of Aromatic Beverages of China Academy of Thermal Sciences, and Associate Professor Cao Jun of Hainan University are the corresponding authors
of the paper 。 This research relies on the Hainan Provincial Key Laboratory of Suitability Processing and Quality Control of Characteristic Tropical Crops, supported by the team members of the Processing and Engineering Technology Research Office of the Institute of Fragrant Beverages/Tropical Woody Grain Research Center of the Chinese Academy of Thermal Sciences, and won the National Natural Science Foundation of China Youth Science Foundation Project (No.
31901649) and the special 2022 science and technology "unveiling" project of the basic scientific research business fund of the academy (No.
1630142022009) Funding
.
Article link: https://doi.
org/10.
3389/fnut.
2022.
1035619
org/10.
3389/fnut.
2022.
1035619
https://doi.
org/10.
1016/j.
jff.
2022.
105195
org/10.
1016/j.
jff.
2022.
105195
