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According to a new study from the National Children's Hospital, a self-renewing brain cell is regulated by circadian rhythms, which provides important insights into
Published in the latest issue of eNeuro, these findings open up new avenues
Many cells in the body follow a 24-hour rhythm, which is genetically driven by them and is known as the circadian clock
"We have found evidence of the role of this well-known molecular pathway — the molecular circadian clock — in regulating the proliferative capacity of NG2 glial cells, both at rest and after injury," said Terry Dean, a critical care specialist at National Children's Hospital and the paper's first author
Sometimes referred to as a "silent epidemic," traumatic brain injuries are afflicted by an estimated 69 million people worldwide each year, ranging from mild concussions to serious injuries that lead to death or lifelong disability
However, there are currently no targeted therapies for traumatic brain injury, so there is an urgent need to discover mechanisms that can unlock the regeneration of these NG2 glial cells, the most common brain cell type known to proliferate and self-renew in the adult brain
Dr Vittorio Gallo, interim chief academic officer and interim director of the National Children's Institute, said: "It is important for researchers to understand that cell renewal is coordinated with the time of
