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4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester, also known as ACE049 or BMP235, is a chemical compound that has shown promising applications in the field of chemical synthesis and pharmaceuticals.
This compound is a derivative of pyrrole, a six-membered aromatic heterocycle that contains a nitrogen atom.
One of the most promising applications of 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester is in the field of organic synthesis.
This compound has been used as a building block for the synthesis of a variety of complex organic molecules, including natural products, pharmaceuticals, and materials.
For example, it has been used in the synthesis of the antimalarial drug artemisinin, which is derived from the plant Artemisia annua.
Another promising application of 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester is in the field of bioconjugation.
This compound can be used to modify biomolecules, such as proteins and small molecules, with high selectivity and efficiency.
This can be useful in a variety of applications, including the development of new therapeutics, diagnostics, and imaging agents.
Recently, 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester has also been shown to have potent and selective inhibitory activity against Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB).
This compound has been shown to be effective against both drug-sensitive and drug-resistant strains of Mtb, making it a promising candidate for the development of new TB treatments.
In addition to its applications in organic synthesis, bioconjugation, and drug discovery, 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester has also shown promise as a catalyst for the polymerization of various monomers.
This compound has been used to polymerize a variety of olefins, including ethylene, propylene, and butylene, as well as vinyl chloride and vinyl acetate.
Overall, 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester is a versatile compound with a wide range of applications in the chemical industry.
Its ability to serve as a building block for organic synthesis, its potential as a catalyst for polymerization, and its potent and selective inhibitory activity against Mycobacterium tuberculosis make it a promising compound for further study and development.