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Importance in cell therapy for bead sorting
Since Emily Whitehead brought new hope for cancer cures, CAR-T cell therapy has once again cemented its central position
Despite the increasing variety of cell sources and types of cell therapy products in the past two years, cell therapy for T cells that are modified for T cells still occupies an important part of
▲ Figure 1 Overview of the production process of CAR-T cell therapy
A growing body of literature suggests that T cell sorting is very important in CAR-T cell preparation, directly affecting the anti-tumor activity
T cell main sorting strategy and products
At present, there are two main strategies
The size of the nano-level magnetic beads on the market is between 50-500 nm, which is divided into column-type sorting and column-free sorting
Another activation sorting strategy for T cells uses micron-level magnetic beads to directly conjugate CD3/CD28 antibodies
Process scale-up and commercialization challenges
China's cell therapy research and development level is now at the same level as the international level, CDE continues to issue new regulations and guidelines, the standardization of cell therapy process also puts forward higher and higher requirements
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