The application and development of fat milk in drug carriers.

Compared with other particle feeding systems, fatty milk has many advantages: the main auxiliary vegetable oil and egg yolk lecithin are non-toxic to the human body, good safety, can use the existing non-gastrointestinal nutrition with fat milk production line for industrial production, can withstand autobaric steam sterilization, the load is higher than lipid body.
fat milk particle size is more than 200-500nm, for the sub-microclinic system, the drug dissolves in the oil phase, or is in the phospholipid shell membrane layer. At present, eight drugs, including fat-soluble
vitamin
, have adopted fat milk-carrying drug technology. They are propofol, eminol, protone, fluorobilofen, tetracycline, palmitic acid dexomison, butyric acid chlorpyrifodine, and fat-soluble vitamins.
the basic prescription and process of fat emulsion are more mature, in which the choice of emulsifying agent is the key to technology. Traditional fat milk with egg yolk lecithin as an emulsifier, has good safety, however, different egg yolk lecithin due to different process, in emulsification performance will be slightly different, especially when the package of drugs this difference will be magnified. In order to solve the stability of fatty milk, some scholars try to study the addition of lysic acid, Polosham and so on as auxiliary emulsifying agents. However, the use of lyoic acid increases the safety risk of the product, and other auxiliary emulsification agents have not been qualified for injection accessories, so at present, the selection of the best performance of egg yolk lecithin solution is the best solution.
addition, there are some scholars by changing the physical and chemical state of the surface of fat milk particles, trying to give fat milk similar to lipid-like long-cycle properties and targeting, is currently a hot topic of research on new drug-carrying fatty milk.
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