That's great! Chinese experts have discovered new anti-cancer molecules that provide a means for precise cancer treatment.

(Health Times network end of the reporter Wei Wei Shanghai Renji Hospital Ye Jiaqi, Yuan Wei)
. Recently, the study conducted by Liu Peifeng team of Liu Peifeng team and Qiu Huibin team of Shanghai Jiaotong University Chemical Institute, affiliated with Shanghai Jiaotong University Chemical College, confirmed for the first time that non-plane polycyclic aromatic aromatic hydrocarbons (PAHs) - small molecule nitrogen helipadene seasonal ammonium salts can selectively kill a variety of tumor cells including liver cancer, lung cancer and leukemia at low concentrations, while the normal cells of the corresponding tissue sources have no obvious toxicity effect.
study has shown that the substance provides a new method for precision treatment of tumors by inducing DNA damage and inhibiting DNA repair, leading to cycle blocking and apoptosis of tumor cells.
the results were published in the international academic journal Advanced Science," entitled "Non-flat aromatics selectively kill tumor cells by inducing DNA damage."cutting-edge scientific journal screenshot
it is well known that the current drug treatment for patients with advanced and middle-stage tumors relies mainly on traditional chemotherapy covered by "no enemy of my cells" and "precise guidance" for molecular proteins in cancer cells.
the former has strong toxic side effects and is prone to drug resistance due to a lack of selectivity, while the latter does not benefit from the treatment of the vast majority of patients with advanced and middle-aged tumors due to a lack of adequate targets. Therefore, the development of new selective broad-spectrum chemotherapy drugs is still the forefront of the current development of tumor drugs.
According to Liu Peifeng, there are many polycyclic aromatic hydrocarbons (PAHs) and their associated derivative compounds in nature, which are considered potentially carcinogenic because PAHs and their derivatives are considered to be potentially carcinogenic, severely limiting their application in the field of biology. In fact, PAHs bind to DNA and have the potential to kill cells. Therefore, if these PAHs can be modified, it will help to turn them from "poisons" to "antidotes".
this study confirms that the carcinogenicity of PAHs and its derivatives is obviously related to their molecular structure, and through structural modification, the author applies non-plane PAH- to the study of tumor therapy for the first time. The study found that helicenium was effective in killing a variety of tumor cells, including liver cancer, lung cancer and leukemia, with no significant effect on normal cells.
in addition, helicenium has a better lethal effect on liver cancer cells than the clinically commonly used chemotherapy drug cisplatin, which will help to address clinical lysupre resistance.the molecular mechanisms of the 4 helicenium selective killer tumor cells
the wide-spectrum selective helicenium found in this study is expected to become a new drug selection and treatment strategy for the precision treatment of tumors, providing new research and development directions in the field of tumor therapy.
The lead technicians of Liu Peifeng's team, Zhou Wei, and Dr. Gan Fuwei of Qiu Huibin's team, are the co-first authors of the thesis; The research was funded by the National Natural Science Foundation of China and other topics.
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