Technology: Pioneering new technologies for exhaling detection and exploring new opportunities for the diagnosis of infectious diseases and tumors

Look and hear, sincerely for the medical program.
cases of patients being diagnosed with the disease through exhaling tests have been going on for decades, and clinical studies over the past few decades have been exploring the guiding significance of exhaling analysis for disease diagnosis.
this led to a new discipline, exhaled metabolomics, which enables diagnosis and monitoring of human health by detecting differences in the distribution of volatile organic compounds (VOCs) in human exhalion.
several in-depth interviews with several clinical respiratory specialists, I found that there was always a clinical need for exhalation detection techniques for disease diagnosis.
"Existing exhalation detection equipment and methods have complex operation, low volume, long time, high cost and many other problems, resulting in exhalation testing in clinical promotion and commercialization has been a huge obstacle."
" Technology is a focus on exhalation detection and disease biomarker research technology enterprises, the company aims to achieve early screening of malignant tumors and infectious diseases through human exhalation detection, for a variety of metabolic-related diseases to provide rapid diagnosis of auxiliary means, for hospitals, scientific research institutions, third-party testing centers and other institutions to provide a new non-invasive, accurate, convenient, low-cost screening and identification diagnostic solutions.
keenly aware of the possible future of the respiratory testing market, Wang Dong-jin had the idea of creating a simple, low-cost, high-volume exhalation detection platform.
by studying relevant literature at home and abroad over the past decade or so, Wang Dong-jian finally found another partner of Ebry Technology, Professor Li Ocean.
Professor Li Ocean is a top expert engaged in high-end analytical instruments and online testing research in China, serving as the leader of the rapid separation and inspection team of Dalian Institute of Chemical Physics of the Chinese Academy of Sciences, a national second-level researcher, doctoral tutor, and currently the chief scientist of Ebry Science and Technology.
With the support of Professor Li Ocean, Wang Dongxian set up the initial research and development team of Ebry Technology in 2015, which was established to carry out clinical research quickly, and to carry out research based on the topic of "the significance of volatile organic matter in human exhaled gas in lung cancer identification testing" in collaboration with the team of Academician Wang Jun of Cardiothoracic Surgery of Peking University People's Hospital.
with the deepening of research, Ebry Technology and Peking University People's Hospital, the Chinese Academy of Sciences Dalian Institute of Chemical Physics jointly set up a "respiratory metabolism research center."
Overcome the barriers to exhalation detection, promote the clinical application process Of Technology for exhalation detection using a self-developed single photon ionization-flight time mass spectrometry (SPI-TOFMS) technology, which can be highly sensitive, real-time, fast measurement of VOCs in exhalation in high humidity environment, with ppt-magnitude detection limit and second-level response speed.
have shown that fingerprinting by detecting VOCs in exhaled air can effectively distinguish between microbial infections in patients.
VoCs contained in the exhalation of the body after human infection with microorganisms mainly come from three aspects: one is the product of the physiological metabolic process of the human body;
once microorganisms invade the body, there are significant differences in metabolites exhaled even during the incubation period.
Therefore, through the analysis of volatile metabolic groups of exhalation traces in human body, it is expected to provide a simple and efficient analysis method for the early rapid detection of infectious diseases, which has important social value and broad clinical application prospects.
In addition to infectious diseases, hypoxia, excessive cell proliferation, excessive inflammation and reactive oxygen activity, and other cancer-related pathological mechanisms can all lead to significant changes in the spectrographs and concentrations of local and systemic VOCs.
means that VOCs can be used as an important marker for making a comprehensive judgment about the physiological and pathological conditions of the human body.
, even though it has been made clear that VOCs fingerprint maps are instructive for the accurate diagnosis of diseases, how to accurately detect VOCs is a difficult problem.
" normal exhaled gas contains saturated water vapor, nitrogen, oxygen and other high concentrations of gases, relatively low VOCs content, usually trace level, in this complex substitlion under the conditions of the common mass spectrometer is difficult to qualitatively quantitative analysis.
" Wang Dong-jian confessed.
Years of investment,
Technology has independently developed a core patented technology, "a new high-pressure photoion source based on vacuum UV lamps", which is a threshold photoionization technology, which releases photon energy that can To achieve the efficient ionation of the vast majority of VOCs in exhalation, and at the same time can not ionumgenation water vapor, carbon dioxide, nitrogen, oxygen and other background parts, so as to eliminate background interference to achieve accurate VOCs analysis, cleverly overcome the technical barriers of exhalation spectrum analysis.
SPI-TOFMS enables exhaled samples without the need for rich direct sample analysis, and enables high-efficiency ionoding and broad-spectrum analysis of small molecule VOCs of different types and properties.
the photoion source used at the same time is a soft ion technology, mainly molecular ions, easy to map the analysis and qualitative quantitative analysis.
Wang Dong-Jian introduced: through SPI-TOFMS to do an exhalation test can be completed at most 60s, test report 1 min can be obtained, currently in tuberculosis, lung cancer, breast cancer and other diseases screening verification to achieve sensitivity and specificity of 90% results.
are also actively conducting clinical trials and will see more good news in the near future.
,000 people blind screening landing, non-invasion early screening has become a reality of Cree technology based on SPI-TOF to achieve human VOCs trace detection, there are obvious clinical application advantages.
in many cancers, digestive diseases, lung diseases, blood infections and other diseases have been documented and experimentally proved its application potential, there are a number of international companies and research and development teams in these directions actively layout.
currently, based on the different VOCs parts detected by exhalation SPI-TOFMS, Photech has pioneered the three major areas of lung cancer, tuberculosis and breast cancer, and several backup adaptive pipelines are also being actively developed.
According to the clinical data already done by Ebry Technology, the sensitivity of 88% to 90% in 1,000 lung cancer tests, 92% to 97% in 1,000 cases of tuberculosis, and 90% in 300 cases of breast cancer detection.
, SPI-TOFMS's early screening of lung cancer can detect in-place adenocarcinoma with a minimum of about 5 mm.
It is worth mentioning that on September 14-17, 2020, Ebry Technology, in cooperation with a CDC affiliated with Changde City, Hunan Province, screened 1,564 new students for tuberculosis, the first time that Gurry Technology has conducted a forward-looking experiment in a real-world scenario.
In this experiment, the only active tuberculosis patient was successfully detected from more than 1,000 enrolled freshmen through SPI-TOFMS exhalation screening, consistent with the CDC's review results, which is a milestone for Ebry Technology.
about the future, Ebry Technology will be strategically screened for multiple cancers and infectious diseases.
multi-cancer detection refers to the one-time screening of multiple cancers at the same time, can effectively reduce cancer morbidity and mortality, is the trend of early screening of cancer.
Wang Dong-Jian admitted that the use of SPI-TOFMS system for the detection and analysis of different cancer species is actually consistent, but the later analysis of mass spectrometry data software differences, which means that the future of Technology Technology through a sampling test to achieve early screening of multiple cancer species.
it is understood that Ernest Technology, which received an angel round of investment from miracle light venture capital funds in 2019, has launched a pre-A round of financing to further accelerate the development and approval process of its product pipelines.
Wang Wei Source: Arterial Network Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mace Medicine" or "Source: MedSci Original" are owned by Mace Medical and may not be reproduced by any media, website or individual without authorization, and shall be reproduced with the words "Source: Mes Medicine".
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