Team of Lin Jun of Changchun Institute of Applied Chemistry/Li Chunxia of Shandong University AS: Noble metal nanoenzyme AuPtAg-GOx induces synergistic tumor immunotherapy induced by starvation therapy to enhance mild photothermal therapy

Innovation: The team broke through the limitation of heat shock proteins (HSPs) blocking low-temperature photothermal therapy, and enhanced AuPtAg-mediated mild photothermal therapy by using glucose oxidase (GOx) to inhibit the production of HSPs at the source and enhance AuPtAg-mediated mild photothermal therapy, thereby activating the systemic immune response
.
AuPtAg-GOx combined with α-PD-L1 can significantly inhibit tumor growth and effectively inhibit lung metastasis
.

Keywords: cascade reactor, immune system activation, mild photothermal therapy, nanozyme, synergistic therapy

In recent years, immunotherapy has made major breakthroughs in the fight against cancer metastasis and recurrence, especially immune checkpoint blocking (ICB) therapy
.
However, due to immunogenic "cold" tumors and lower levels of tumor-infiltrating lymphocytes (TILs), a single ICB treatment is usually less effective
.
Fortunately, the shortcomings of ICB-based treatment can be compensated for by synergistic therapy, which brings new hope
for effective cancer suppression.

In view of this, Professor Li Chunxia of Shandong University and researcher Lin Jun of the Chunying Institute of Chinese Sciences, Dean of Chinese Sciences, designed an AuPtAg-GOx nanoenzyme for co-tumor immunotherapy
induced by starvation therapy and mild photothermal therapy.
AuPtAg is first synthesized by a one-pot method, and then covalently attached to its surface
with SH-PEG-NH₂ as a bridge.
AuPtAg-GOx with catalase-like activity can catalyze the conversion of overexpressed_H2O2into_O2
within tumors.
AuPtAg-GOx then achieves a significant starvation treatment effect
by depleting glucose with the help of_O2.
In addition, the cutting off of nutrients leads to a decrease
in ATP levels within the tumor.
After laser irradiation at 1064 nm, AuPtAg-GOx generates mild heat
in the tumor area.
At the same time, limited ATP levels can inhibit the synthesis of heat shock proteins (HSPs), enabling gentle photothermal therapy (PTT).

Mild PTT exacerbates recruitment of TILs, which reprogram "cold" tumors and increase the sensitivity of ICB treatment
.
Therefore, by combining AuPtAg-GOx with α-PD-L1, primary and distal tumors
can be effectively suppressed.
In short, AuPtAg-GOx can enhance mild PTT with starvation therapy and further enhance immunotherapy efficacy
with mild PTT.
This cascade promotion synergistic strategy provides a new way of thinking
for efficient cancer treatment.

WILEY

Paper Information:

A Noble AuPtAg-GOx Nanozyme for Synergistic Tumor Immunotherapy Induced by Starvation Therapy-Augmented Mild Photothermal Therapy

Man Wang, Mengyu Chang, Pan Zheng, Qianqian Sun, Guangqiang Wang, Jun Lin,* and Chunxia Li*

Advanced Science

DOI: 10.
1002/advs.
202202332

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