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Suppress inflammation and fibrosis FDA approves the first ROCK2 inhibitor

 Last Update: 2021-08-03
 Source: Internet
 Author: User

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Recently, Kadmon announced that the US FDA approved the company's Rezurock (belumosudil) for the treatment of chronic graft-versus-host disease (cGVHD) patients over 12 years of age who have received two pre-systemic treatments

Hematopoietic stem cell transplantation is a common treatment for blood or bone marrow cancer

As a ROCK2 kinase inhibitor, belumosudil can reduce the phosphorylation of STAT3 and strengthen the phosphorylation of STAT5, thereby down-regulating over-activated T helper cells (Th17) and enhancing the function of regulatory T cells (Treg), thereby rebuilding immune balance

▲Illustration of the mechanism of action of Belumosudil (picture source: reference [2])

The FDA approval is based on the results of a random, open-label, multi-center pivotal clinical trial called ROCKstar

"Rezurock is a new treatment model for thousands of cGVHD patients

Reference materials:

[1] US FDA Grants Full Approval of REZUROCK(TM) (belumosudil) for the Treatment of Patients with Chronic Graft-Versus-Host Disease (cGVHD).

[2] Kadmon Corporate Presentation.

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